Novel antiviral strategies to combat human Arenavirus infections.

Details

Serval ID
serval:BIB_E4E8C1954A4C
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Novel antiviral strategies to combat human Arenavirus infections.
Journal
Current Molecular Medicine
Author(s)
Kunz S., de la Torre J.C.
ISSN
1566-5240 (Print)
ISSN-L
1566-5240
Publication state
Published
Issued date
2005
Volume
5
Number
8
Pages
735-751
Language
english
Abstract
Arenaviruses merit significant attention both as tractable model systems to study acute and persistent viral infections, and as clinically important human pathogens. Evidence indicates that LCMV remains present in the USA and Europe and capable of causing significant morbidity in infected individuals, likely being a neglected human pathogen. Moreover, new arenaviruses are being discovered in the Americas on the average of one every three years, with some of them causing severe hemorrhagic fever. In addition, weaponized forms of these viruses pose a real threat as agents of bioterrorism. Therefore, it is important to develop effective vaccines and better antiviral drugs to combat the dual threats of naturally occurring and intentionally introduced Arenavirus infections. The development of arenavirus reverse genetic systems is allowing investigators to conduct a detailed molecular characterization of the viral cis-acting signals and trans-acting factors that control each of the steps of the Arenavirus life cycle, including RNA synthesis, packaging and budding. We will discuss how this new knowledge is facilitating the establishment of novel assays to identify and characterize compounds capable of interfering with specific steps of the virus life cycle. Likewise, the ability to generate predetermined specific mutations within the arenavirus genome, and analyze their phenotypic expression, would significantly contribute to the elucidation of arenavirus-host interactions, including the bases of their ability to persist, as well as to cause severe HF (hemorrhagic fever) disease in humans. These approaches could also lead to the development of novel potent and safe Arenavirus vaccines.
Keywords
Antibodies, Viral/therapeutic use, Antiviral Agents/pharmacology, Arenaviridae/drug effects, Arenaviridae/genetics, Arenaviridae Infections/drug therapy, Arenaviridae Infections/epidemiology, Humans, Lymphocytic choriomeningitis virus/drug effects, Lymphocytic choriomeningitis virus/genetics, Viral Vaccines
Pubmed
Web of science
Create date
17/04/2013 16:46
Last modification date
20/08/2019 16:08
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