Structural Brain Volume Covariance Associated with Gait Speed in Patients with Amnestic and Non-Amnestic Mild Cognitive Impairment: A Double Dissociation.

Details

Serval ID
serval:BIB_E4C8C17DFF2B
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Structural Brain Volume Covariance Associated with Gait Speed in Patients with Amnestic and Non-Amnestic Mild Cognitive Impairment: A Double Dissociation.
Journal
Journal of Alzheimer's disease
Author(s)
Allali G., Montembeault M., Saj A., Wong C.H., Cooper-Brown L.A., Bherer L., Beauchet O.
ISSN
1875-8908 (Electronic)
ISSN-L
1387-2877
Publication state
Published
Issued date
2019
Peer-reviewed
Oui
Volume
71
Number
s1
Pages
S29-S39
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Gait impairment is observed in early stages of dementia, such as mild cognitive impairment (MCI), and is associated with morphological brain volume changes like atrophy.
This study aims to characterize the brain's grey matter (GM) volume covariance associated with gait speed in patients with amnestic mild cognitive impairment (aMCI) and non-amnestic MCI (naMCI).
Gait speed was measured in 171 patients with MCI (age 72.0±5.1; 36.8% female; 41 with aMCI and 130 naMCI) at normal and rapid gait speeds. Brain GM covariance networks were computed using voxel-based morphometry, using the main neural correlates of gait speed in each group and for each walking condition as seed regions.
Normal gait speed correlated with GM volume in the left frontal cortex in patients with aMCI, and in bilateral caudate and left putamen in those with naMCI. Rapid gait speed correlated with GM volume in the bilateral caudate and right cerebellum in naMCI, but without any GM region in aMCI. For normal gait speed, the left caudate nucleus volume in naMCI covaried with subcortico-frontal regions, while the left frontal cortex covaried with cortical regions involving the frontal cortex in aMCI. For rapid gait speed, subcortico-frontal regions were similar as for normal speed in naMCI.
Brain GM volume covariance associated with gait speed varies according to the type of MCI; it involved subcortico-frontal regions for patients with naMCI and the frontal cortex in those with aMCI.
Keywords
Aged, Amnesia/diagnostic imaging, Amnesia/pathology, Amnesia/physiopathology, Brain/diagnostic imaging, Brain/pathology, Cognitive Dysfunction/diagnostic imaging, Cognitive Dysfunction/pathology, Cognitive Dysfunction/physiopathology, Cognitive Dysfunction/psychology, Cross-Sectional Studies, Female, Gray Matter/diagnostic imaging, Gray Matter/pathology, Humans, Magnetic Resonance Imaging, Male, Neuropsychological Tests, Organ Size, Walking Speed, Alzheimer’s disease, anatomical structural covariance, gait, mild cognitive impairment, neuroimaging
Pubmed
Web of science
Create date
04/10/2023 22:42
Last modification date
05/10/2023 6:59
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