ITPA gene variants protect against anaemia in patients treated for chronic hepatitis C.

Details

Serval ID
serval:BIB_E494E62E3073
Type
Article: article from journal or magazin.
Collection
Publications
Title
ITPA gene variants protect against anaemia in patients treated for chronic hepatitis C.
Journal
Nature
Author(s)
Fellay J., Thompson A.J., Ge D., Gumbs C.E., Urban T.J., Shianna K.V., Little L.D., Qiu P., Bertelsen A.H., Watson M., Warner A., Muir A.J., Brass C., Albrecht J., Sulkowski M., McHutchison J.G., Goldstein D.B.
ISSN
1476-4687 (Electronic)
ISSN-L
0028-0836
Publication state
Published
Issued date
2010
Peer-reviewed
Oui
Volume
464
Number
7287
Pages
405-408
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Chronic infection with the hepatitis C virus (HCV) affects 170 million people worldwide and is an important cause of liver-related morbidity and mortality. The standard of care therapy combines pegylated interferon (pegIFN) alpha and ribavirin (RBV), and is associated with a range of treatment-limiting adverse effects. One of the most important of these is RBV-induced haemolytic anaemia, which affects most patients and is severe enough to require dose modification in up to 15% of patients. Here we show that genetic variants leading to inosine triphosphatase deficiency, a condition not thought to be clinically important, protect against haemolytic anaemia in hepatitis-C-infected patients receiving RBV.
Keywords
Alleles, Anemia, Hemolytic/chemically induced, Anemia, Hemolytic/complications, Antiviral Agents, Chromosomes, Human, Pair 20, Continental Population Groups/genetics, Europe/ethnology, Genetic Variation/genetics, Genome-Wide Association Study, Hemoglobins/deficiency, Hemoglobins/metabolism, Hepatitis C, Chronic/complications, Hepatitis C, Chronic/drug therapy, Humans, Polymorphism, Single Nucleotide/genetics, Pyrophosphatases/deficiency, Pyrophosphatases/genetics, Ribavirin/therapeutic use, United States
Pubmed
Web of science
Create date
01/03/2012 15:14
Last modification date
20/08/2019 16:08
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