Cytogenetic analysis of 570 first trimester chorionic villi samplings: technique and results.

Details

Serval ID
serval:BIB_E48FBB34CBD2
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Cytogenetic analysis of 570 first trimester chorionic villi samplings: technique and results.
Journal
Annales de Génétique
Author(s)
Jotterand-Bellomo  M., Pescia  G., Nguyen The  H., Gaide  A. C., Thonney  F., Marguerat  P., Paccaud  F., Munier  F.
ISSN
0003-3995 (Print)
Publication state
Published
Issued date
1988
Volume
31
Number
1
Pages
14-20
Language
english
Notes
Journal Article
Abstract
In this report we present our experience based on 570 chorionic villi samplings performed by the transcervical method at 8 to 12 weeks gestation. Cytogenetic results were obtained for 551 samples, hence a failure rate of 3.33%. The previously described technique was modified by prolonging the incubation period to 48 hours. The total number of abnormalities was 26, which represents 4.71% of our sample. Of 24 chromosomal abnormalities, 21 were unbalanced and 3 were balanced of parental origin. Five discordant cases are thoroughly discussed.
Keywords
Chorionic Villi/*ultrastructure Chromosome Aberrations/*diagnosis Chromosome Disorders Female Humans Methods Pregnancy Pregnancy Trimester, First *Prenatal Diagnosis Sex Chromosome Aberrations/diagnosis
Pubmed
Web of science
Create date
28/01/2008 12:54
Last modification date
20/08/2019 16:08
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