Fatal intrahepatic hemorrhage after nadroparin use for total hip arthroplasty.

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Serval ID
serval:BIB_E46ABD7A3732
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Fatal intrahepatic hemorrhage after nadroparin use for total hip arthroplasty.
Journal
Forensic Science, Medicine, and Pathology
Author(s)
Ventura F., Bonsignore A., De Stefano F., Pizzorno E., Palmiere C.
ISSN
1556-2891 (Electronic)
ISSN-L
1547-769X
Publication state
Published
Issued date
2014
Peer-reviewed
Oui
Volume
10
Number
4
Pages
619-622
Language
english
Notes
Publication types: Publication Status: ppublish
Abstract
Low-molecular-weight heparins have become the predominant choice for deep venous thrombosis prophylaxis and treatment. However, their use may cause bleeding complications. Intrahepatic bleeding is exceptional and only very few cases have been described. The authors present a unique case of fatal intrahepatic hematoma complicating nadroparin use in a 65-year-old woman with a hepatic cyst who was admitted to hospital for unilateral total hip arthroplasty. At autopsy, hemoperitoneum (2,000 ml of blood and clots) was evident. A ruptured sub-capsular hematoma involving the right lobe of the liver was observed. The hemorrhage within the cyst induced by the nadroparin use was likely responsible for the subsequent hepatic hematoma, liver rupture, and death. This case highlights the need for pathologists and surgeons to be aware of the possibility of intrahepatic hematoma in patients who have received low-molecular-weight heparins, undergone major surgery and present postoperative hemodynamic instability, especially in those with preoperative diagnosis of hepatic cyst.
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Web of science
Create date
18/12/2014 18:29
Last modification date
09/09/2021 6:14
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