Astrocytes mediate the effect of oxytocin in the central amygdala on neuronal activity and affective states in rodents.

Details

Serval ID
serval:BIB_E466E56765BD
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Astrocytes mediate the effect of oxytocin in the central amygdala on neuronal activity and affective states in rodents.
Journal
Nature Neuroscience
Author(s)
Wahis J., Baudon A., Althammer F., Kerspern D., Goyon S., Hagiwara D., Lefevre A., Barteczko L., Boury-Jamot B., Bellanger B., Abatis M., Da Silva Gouveia M., Benusiglio D., Eliava M., Rozov A., Weinsanto I., Knobloch-Bollmann H.S., Kirchner M.K., Roy R.K., Wang H., Pertin M., Inquimbert P., Pitzer C., Siemens J., Goumon Y., Boutrel B., Lamy C.M., Decosterd I., Chatton J.-Y., Rouach N., Young W.S., Stern J.E., Poisbeau P., Stoop R., Darbon P., Grinevich V., Charlet A.
ISSN
1546-1726 (Electronic)
ISSN-L
1097-6256
Publication state
Published
Issued date
04/2021
Peer-reviewed
Oui
Volume
24
Number
4
Pages
529-541
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Oxytocin (OT) orchestrates social and emotional behaviors through modulation of neural circuits. In the central amygdala, the release of OT modulates inhibitory circuits and, thereby, suppresses fear responses and decreases anxiety levels. Using astrocyte-specific gain and loss of function and pharmacological approaches, we demonstrate that a morphologically distinct subpopulation of astrocytes expresses OT receptors and mediates anxiolytic and positive reinforcement effects of OT in the central amygdala of mice and rats. The involvement of astrocytes in OT signaling challenges the long-held dogma that OT acts exclusively on neurons and highlights astrocytes as essential components for modulation of emotional states under normal and chronic pain conditions.
Keywords
Animals, Astrocytes/drug effects, Astrocytes/metabolism, Behavior, Animal/drug effects, Behavior, Animal/physiology, Central Amygdaloid Nucleus/drug effects, Central Amygdaloid Nucleus/metabolism, Emotions/physiology, Female, Male, Mice, Mice, Inbred C57BL, Neurons/metabolism, Oxytocin/metabolism, Oxytocin/pharmacology, Rats, Rats, Wistar, Receptors, Oxytocin/metabolism
Pubmed
Web of science
Create date
22/02/2021 10:03
Last modification date
07/07/2021 5:36
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