The epidthelial sodium channel ENaC and its regulators in the epidermal permeability barrier function
Details
State: Public
Version: Final published version
Serval ID
serval:BIB_E45C10BB88B1
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
The epidthelial sodium channel ENaC and its regulators in the epidermal permeability barrier function
Journal
The Open Dermatology Journal
ISSN
1874-3722
Publication state
Published
Issued date
2010
Peer-reviewed
Oui
Volume
4
Pages
27-35
Language
english
Abstract
The highly amiloride-sensitive epithelial sodium channel ENaC is well known to be involved in controlling whole body sodium homeostasis and lung liquid clearance. ENaC expression has also been detected in the skin of amphibians and mammals. Mice lacking ENaC expression lose rapidly weight associated with an epidermal barrier defect that develops following birth. This dehydration is accompanied with a highly abnormal lipid matrix composition and an impaired skin surface acidification. This strongly suggests a role of ENaC in the maturation of barrier function rather than in the prenatal generation of the barrier, and may be as such an important modulator for skin hydration. In parallel, gene targeting experiments of regulators of ENaC activity, membrane serine proteases, also termed channel activating proteases, like CAP1/Prss8 and matriptase/MT-SP1 by themselves have been shown to be crucial for the epidermal barrier function. In our review, we mainly focus on the role of ENaC and its regulators in the skin and discuss their importance in the epidermal permeability barrier function.
Keywords
Sodium channel, transmembrane ion flux, regulators of ENaC, serine protease, barrier dysfunction
Open Access
Yes
Create date
18/11/2010 18:11
Last modification date
20/10/2020 15:41