Physical performance limitations in adolescent and adult survivors of childhood cancer and their siblings.

Details

Ressource 1Download: BIB_E44EB0398864.P001.pdf (271.63 [Ko])
State: Public
Version: author
Serval ID
serval:BIB_E44EB0398864
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Physical performance limitations in adolescent and adult survivors of childhood cancer and their siblings.
Journal
Plos One
Author(s)
Rueegg C.S., Michel G., Wengenroth L., von der Weid N.X., Bergstraesser E., Kuehni C.E.
Working group(s)
Swiss Paediatric Oncology Group (SPOG)
Contributor(s)
Ammann R., Angst R., Beck Popovic M., Bergstraesser E., Brazzola P., Caflisch U., Greiner J., Grotzer M., Hengartner H., Kühne T., Leibundgut K., Niggli F., Nobile Buetti L., Ozsahin H., Paulussen M., Rischewski J., von der Weid N.
ISSN
1932-6203 (Electronic)
ISSN-L
1932-6203
Publication state
Published
Issued date
2012
Peer-reviewed
Oui
Volume
7
Number
10
Pages
e47944
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
PURPOSE: This study investigates physical performance limitations for sports and daily activities in recently diagnosed childhood cancer survivors and siblings.
METHODS: The Swiss Childhood Cancer Survivor Study sent a questionnaire to all survivors (≥ 16 years) registered in the Swiss Childhood Cancer Registry, who survived >5 years and were diagnosed 1976-2003 aged <16 years. Siblings received similar questionnaires. We assessed two types of physical performance limitations: 1) limitations in sports; 2) limitations in daily activities (using SF-36 physical function score). We compared results between survivors diagnosed before and after 1990 and determined predictors for both types of limitations by multivariable logistic regression.
RESULTS: The sample included 1038 survivors and 534 siblings. Overall, 96 survivors (9.5%) and 7 siblings (1.1%) reported a limitation in sports (Odds ratio 5.5, 95%CI 2.9-10.4, p<0.001), mainly caused by musculoskeletal and neurological problems. Findings were even more pronounced for children diagnosed more recently (OR 4.8, CI 2.4-9.6 and 8.3, CI 3.7-18.8 for those diagnosed <1990 and ≥ 1990, respectively; p=0.025). Mean physical function score for limitations in daily activities was 49.6 (CI 48.9-50.4) in survivors and 53.1 (CI 52.5-53.7) in siblings (p<0.001). Again, differences tended to be larger in children diagnosed more recently. Survivors of bone tumors, CNS tumors and retinoblastoma and children treated with radiotherapy were most strongly affected.
CONCLUSION: Survivors of childhood cancer, even those diagnosed recently and treated with modern protocols, remain at high risk for physical performance limitations. Treatment and follow-up care should include tailored interventions to mitigate these late effects in high-risk patients.
Keywords
Activities of Daily Living, Adolescent, Adult, Child, Female, Humans, Male, Motor Activity, Neoplasms/complications, Neoplasms/physiopathology, Questionnaires, Siblings, Sports, Survivors, Young Adult
Pubmed
Web of science
Open Access
Yes
Create date
20/12/2012 18:55
Last modification date
20/08/2019 16:07
Usage data