Sex differences across developmental domains among children with a familial risk of severe mental disorders.

Details

Serval ID
serval:BIB_E44D937BCD2A
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Sex differences across developmental domains among children with a familial risk of severe mental disorders.
Journal
Psychological medicine
Author(s)
Burton B.K., Andersen K.K., Greve A.N., Hemager N., Spang K.S., Ellersgaard D., Christiani C.J., Gantriis D., Gregersen M., Søndergaard A., Jepsen JRM, Bliksted V.F., Mors O., Plessen K.J., Nordentoft M., Thorup AAE
ISSN
1469-8978 (Electronic)
ISSN-L
0033-2917
Publication state
In Press
Peer-reviewed
Oui
Pages
1-16
Language
english
Notes
Publication types: Journal Article
Publication Status: aheadofprint
Abstract
Sex differences in brain structure and neurodevelopment occur in non-clinical populations. We investigated whether sex had a similar effect on developmental domains amongst boys and girls with a familial risk of schizophrenia (FHR-SZ), bipolar disorder (FHR-BP), and controls.
Through Danish registries, we identified 522 7-year-old children (242 girls) with FHR-SZ, FHR-BP, and controls. We assessed their performance within the domains of neurocognition, motor function, language, social cognition, social behavior, psychopathology, and home environment.
FHR-SZ boys compared with FHR-SZ girls had a higher proportion of disruptive behavior and attention-deficit hyperactivity disorder (ADHD) and exhibited lower performance in manual dexterity, balance, and emotion recognition. No sex differences were found between boys and girls within FHR-BP group. Compared with controls, both FHR-SZ boys and FHR-SZ girls showed impaired processing speed and working memory, had lower levels of global functioning, and were more likely to live in an inadequate home environment. Compared with control boys, FHR-SZ boys showed impaired manual dexterity, social behavior, and social responsiveness, and had a higher proportion of ADHD and disruptive behavior disorder diagnoses. Stress and adjustment disorders were more common in FHR-BP boys compared with control boys. We found no differences between FHR-BP girls and control girls.
Impairment within neurodevelopmental domains associated within FHR-SZ boys v. FHR-SZ girls was most evident among boys, whereas no sex differences were found within the FHR-BP group (FHR-BP boys v. FHR-BP girls). FHR-SZ boys exhibited the highest proportion of early developmental impairments.
Keywords
Bipolar disorder, motor, neurocognition, psychopathology, schizophrenia, sex
Pubmed
Create date
19/02/2022 11:21
Last modification date
02/11/2022 6:41
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