Combined radioimmunotherapy and radiotherapy of human colon carcinoma grafted in nude mice

Details

Serval ID
serval:BIB_E449CFCAC2A5
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Combined radioimmunotherapy and radiotherapy of human colon carcinoma grafted in nude mice
Journal
Cancer Research
Author(s)
Buchegger  F., Rojas  A., Bischof Delaloye A., Vogel  C. A., Mirimanoff  R. O., Coucke  P., Sun  L. Q., Raimondi  S., Denekamp  J., Pelgrin  A., Delaloye  B., Mach  JP.
ISSN
0008-5472 (Print)
Publication state
Published
Issued date
01/1995
Volume
55
Number
1
Pages
83-9
Notes
Journal Article Research Support, Non-U.S. Gov't --- Old month value: Jan 1
Abstract
The effect of combined radioimmunotherapy (RIT) and fractionated external beam radiotherapy (RT) was assessed in two human colon cancer xenografts, Co112 and LS174T in nude mice. These tumors were selected for being resistant to RIT alone, as is usually the case in the clinical situation. Tumor-bearing mice were treated with a combination of five X-ray fractions over 5 days followed by RIT with two doses of 1.5 mCi 131I-labeled anticarcinoembryonic antigen monoclonal antibody F(ab')2. In Co112 and LS174T, RIT alone achieved a regrowth delay similar to that of fractionated RT with total doses of 28 and 26 Gy, respectively. In both tumor types, an additive therapeutic effect, measured as increased regrowth delay or local control, was observed when combining RT of different dose levels with RIT. Normal tissue responses were assessed by monitoring acute peak skin reactions and blood cell count. Bone marrow depression for the combination treatment was similar to that of RIT alone; relative to skin, at equitoxic levels, no mice bearing Co112 tumors were locally controlled with a 32 Gy RT dose alone, while this RT combined with RIT gave a local control of 100%. These studies show a therapeutic benefit when external beam RT is combined with RIT.
Keywords
Animals Antibodies, Monoclonal/therapeutic use Blood/radiation effects Bone Marrow/radiation effects Carcinoembryonic Antigen/*immunology Colonic Neoplasms/*radiotherapy Combined Modality Therapy/adverse effects Female Humans Iodine Radioisotopes/*therapeutic use Mice Mice, Nude Neoplasm Transplantation Radioimmunotherapy Skin Diseases/etiology Time Factors Transplantation, Heterologous
Pubmed
Web of science
Create date
24/01/2008 17:12
Last modification date
20/08/2019 16:07
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