Multiple roles of lymphatic vessels in peripheral lymph node development.

Details

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Version: Final published version
Serval ID
serval:BIB_E43336AE208C
Type
Article: article from journal or magazin.
Collection
Publications
Title
Multiple roles of lymphatic vessels in peripheral lymph node development.
Journal
The Journal of Experimental Medicine
Author(s)
Bovay E., Sabine A., Prat-Luri B., Kim S., Son K., Willrodt A.H., Olsson C., Halin C., Kiefer F., Betsholtz C., Jeon N.L., Luther S.A., Petrova T.V.
ISSN
1540-9538 (Electronic)
ISSN-L
0022-1007
Publication state
Published
Issued date
2018
Peer-reviewed
Oui
Volume
215
Number
11
Pages
2760-2777
Language
english
Abstract
The mammalian lymphatic system consists of strategically located lymph nodes (LNs) embedded into a lymphatic vascular network. Mechanisms underlying development of this highly organized system are not fully understood. Using high-resolution imaging, we show that lymphoid tissue inducer (LTi) cells initially transmigrate from veins at LN development sites using gaps in venous mural coverage. This process is independent of lymphatic vasculature, but lymphatic vessels are indispensable for the transport of LTi cells that egress from blood capillaries elsewhere and serve as an essential LN expansion reservoir. At later stages, lymphatic collecting vessels ensure efficient LTi cell transport and formation of the LN capsule and subcapsular sinus. Perinodal lymphatics also promote local interstitial flow, which cooperates with lymphotoxin-β signaling to amplify stromal CXCL13 production and thereby promote LTi cell retention. Our data unify previous models of LN development by showing that lymphatics intervene at multiple points to assist LN expansion and identify a new role for mechanical forces in LN development.
Pubmed
Web of science
Open Access
Yes
Create date
05/11/2018 9:30
Last modification date
20/08/2019 17:07
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