Effect of treatment sequence in combined intrastromal corneal rings and corneal collagen crosslinking for keratoconus.

Details

Serval ID
serval:BIB_E417FD772CDE
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Effect of treatment sequence in combined intrastromal corneal rings and corneal collagen crosslinking for keratoconus.
Journal
Journal of cataract and refractive surgery
Author(s)
Coskunseven E., Jankov M.R., Hafezi F., Atun S., Arslan E., Kymionis G.D.
ISSN
1873-4502 (Electronic)
ISSN-L
0886-3350
Publication state
Published
Issued date
12/2009
Peer-reviewed
Oui
Volume
35
Number
12
Pages
2084-2091
Language
english
Notes
Publication types: Comparative Study ; Journal Article ; Randomized Controlled Trial
Publication Status: ppublish
Abstract
To compare 2 sequences of combined intrastromal corneal ring segment (ICRS) implantation and ultraviolet/riboflavin-mediated corneal collagen crosslinking (CXL) in progressive keratoconus.
Dunya Eye Hospital, Istanbul, Turkey.
In this prospective comparative randomized consecutive study, CXL was followed by ICRS implantation (Group 1) or ICRS implantation was followed by CXL (Group 2). Uncorrected (UDVA) and corrected (CDVA) distance visual acuities, spherical equivalent (SE), manifest cylinder (cylinder), and mean keratometry (K) were compared preoperatively and postoperatively.
The mean interval between treatments was 7 months +/- 2 (SD) (mean follow-up, 13 +/- 1 months). The mean UDVA and CDVA improved in both groups (UDVA: 0.07 +/- 0.09 to 0.25 +/- 0.12, Group 1, and 0.11 +/- 0.09 to 0.32 +/- 0.21, Group 2; CDVA: 0.24 +/- 0.11 to 0.41 +/- 0.20 and 0.22 +/- 0.16 to 0.55 +/- 0.2, respectively). The mean SE, cylinder, and mean K values decreased in both groups (SE: -7.13 +/- 3.34 D to -2.98 +/- 2.33 D, Group 1, and -7.05 +/- 5.54 D to -2.81 +/- 4.08 D, Group 2; cylinder: -4.38 +/- 2.03 D to -2.62 +/- 1.93 D and -4.68 +/- 2.60 D to -2.20 +/- 1.67 D, respectively; mean K: 52.47 +/- 4.01 D to 48.31 +/- 3.65 D and 52.06 +/- 4.93 D to 48.08 +/- 4.13 D, respectively). Overall, there was more improvement in CDVA, SE, and mean K in Group 2 than in Group 1.
Implantation of ICRS followed by CXL resulted in greater improvement of keratoconus.
Keywords
Adolescent, Adult, Collagen/metabolism, Combined Modality Therapy, Corneal Stroma/metabolism, Corneal Stroma/radiation effects, Corneal Stroma/surgery, Female, Humans, Keratoconus/drug therapy, Keratoconus/surgery, Keratoconus/therapy, Male, Photosensitizing Agents/therapeutic use, Prospective Studies, Prostheses and Implants, Prosthesis Implantation, Riboflavin/therapeutic use, Treatment Outcome, Ultraviolet Rays, Visual Acuity, Young Adult
Pubmed
Web of science
Create date
01/10/2019 15:39
Last modification date
06/10/2019 5:26
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