Developments in liver transplantation for hepatocellular carcinoma.

Details

Serval ID
serval:BIB_E412B633EC4E
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Developments in liver transplantation for hepatocellular carcinoma.
Journal
Seminars in oncology
Author(s)
Melloul E., Lesurtel M., Carr B.I., Clavien P.A.
ISSN
1532-8708 (Electronic)
ISSN-L
0093-7754
Publication state
Published
Issued date
08/2012
Volume
39
Number
4
Pages
510-521
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
Hepatocellular carcinoma (HCC) is a serious health problem worldwide because of its association with hepatitis B and C viruses. In this setting, liver transplantation (LT) has become one of the best treatments since it removes both the tumor and the underlying liver disease. Due to the improvement of imaging techniques and surveillance programs, HCC are being detected earlier at a stage at which effective treatment is feasible. The prerequisite for long term success of LT for HCC depends on tumor load and strict selection criteria with regard to the size and number of tumor nodules. The need to obtain the optimal benefit from the limited number of organs available has prompted the maintenance of selection criteria in order to list only those patients with early HCC who have a better long-term outcome after LT. The indications for LT and organ allocation system led to many controversies around the use of LT in HCC patients. This review aims at giving the latest updated developments in LT for HCC focusing on selection criteria, diagnostic tools, prognostic factors, treatment on the waiting list, role of living donor liver transplantation and adjuvant therapy, and the impact of immunosuppression on HCC recurrence after LT.

Keywords
Carcinoma, Hepatocellular/pathology, Carcinoma, Hepatocellular/surgery, Humans, Immunosuppression, Liver Neoplasms/pathology, Liver Neoplasms/surgery, Liver Transplantation, Living Donors, Neoadjuvant Therapy, Neoplasm Invasiveness
Pubmed
Create date
15/02/2017 10:47
Last modification date
20/08/2019 16:07
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