Sustained-release steroids for the treatment of diabetic macular edema.

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State: Public
Version: Author's accepted manuscript
Serval ID
serval:BIB_E40C429E7127
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Sustained-release steroids for the treatment of diabetic macular edema.
Journal
Current Diabetes Reports
Author(s)
Daruich A., Matet A., Behar-Cohen F.
ISSN
1539-0829 (Electronic)
ISSN-L
1534-4827
Publication state
Published
Issued date
2015
Peer-reviewed
Oui
Volume
15
Number
11
Pages
99
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
Glucocorticoids have been used for decades in the treatment of ocular disorders via topical, periocular, and more recently intravitreal routes. However, their exact mechanisms of action on ocular tissues remain imperfectly understood. Fortunately, two recently approved intravitreal sustained-release drug delivery systems have opened new perspectives for these very potent drugs. To date, among other retinal conditions, their label includes diabetic macular edema, for which a long-lasting therapeutic effect has been demonstrated both morphologically and functionally in several randomized clinical trials. The rate of ocular complications of intravitreal sustained-release steroids, mainly cataract formation and intraocular pressure elevation, is higher than with anti-vascular endothelial growth factor agents. Yet, a better understanding of the mechanisms underlying these adverse effects and the search for the minimal efficient dose should help optimize their therapeutic window.
Keywords
Animals, Clinical Trials as Topic, Delayed-Action Preparations, Diabetes Complications/drug therapy, Diabetes Complications/metabolism, Glucocorticoids/therapeutic use, Humans, Macular Edema/drug therapy, Macular Edema/etiology, Steroids/metabolism, Treatment Outcome
Pubmed
Web of science
Open Access
Yes
Create date
29/09/2015 8:12
Last modification date
20/08/2019 16:07
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