The long-term effect of repeated intravenous lidocaine on central pain and possible correlation in positron emission tomography measurements.

Details

Serval ID
serval:BIB_E3BCAFF4CCED
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
The long-term effect of repeated intravenous lidocaine on central pain and possible correlation in positron emission tomography measurements.
Journal
Anesthesia and Analgesia
Author(s)
Cahana A., Carota A., Montadon M.L., Annoni J.M.
ISSN
0003-2999
Publication state
Published
Issued date
2004
Peer-reviewed
Oui
Volume
98
Number
6
Pages
1581-1584
Language
english
Notes
Case Reports Journal Article --- Old month value: Jun
Abstract
Functional neuroimaging suggests that similar brain regions are involved in the processing of pain in healthy subjects and in patients with chronic neuropathic central pain. We present a patient with chronic neuropathic central pain due to a unique lesion to the trigeminal and spinothalamic pathway who had persistent pain relief after repeated IV lidocaine infusions. Positron emission tomography scan results showed a relative hypoactivity of the left posterolateral thalamus before treatment which disappeared after therapy. This case may suggest a stereo-selective analgesic effect of lidocaine accompanied by regional cerebral blood flow changes in the thalamus, indicating that sodium channels could, in fact, be highly expressed or modified in the thalamus after thalamic deafferentation. IMPLICATIONS: We present a case of persistent central pain after encephalitis in a patient who had long-term pain relief after a series of IV lidocaine infusions. A positron emission tomography scan study, done before and after treatment, suggested that lidocaine for the diagnosis of chronic neuropathic pain may have a specific site of action in the brain.
Keywords
Aged, Female, Humans, Infusions, Intravenous, Lidocaine, Pain, Pons, Thalamus, Time, Tomography, Emission-Computed
Pubmed
Web of science
Create date
25/01/2008 11:37
Last modification date
20/08/2019 16:07
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