Exploring the Prognostic Role of Ki67 Proliferative Index in Merkel Cell Carcinoma of the Skin: Clinico-Pathologic Analysis of 84 Cases and Review of the Literature.

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State: Public
Version: Final published version
License: CC BY-ND 4.0
Serval ID
serval:BIB_E38E64B33412
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Exploring the Prognostic Role of Ki67 Proliferative Index in Merkel Cell Carcinoma of the Skin: Clinico-Pathologic Analysis of 84 Cases and Review of the Literature.
Journal
Endocrine pathology
Author(s)
La Rosa S., Bonzini M., Sciarra A., Asioli S., Maragliano R., Arrigo M., Foschini M.P., Righi A., Maletta F., Motolese A., Papotti M., Sessa F., Uccella S.
ISSN
1559-0097 (Electronic)
ISSN-L
1046-3976
Publication state
Published
Issued date
12/2020
Peer-reviewed
Oui
Volume
31
Number
4
Pages
392-400
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
The exact prediction of outcome of patients with Merkel cell carcinoma (MCC) of the skin is difficult to determine, although several attempts have been made to identify clinico-pathologic prognostic factors. The Ki67 proliferative index is a well-known marker routinely used to define the prognosis of patients with neuroendocrine neoplasms. However, its prognostic value has been poorly investigated in MCC, and available published results are often contradictory mainly because restricted to small series in the absence of standardized methods for Ki67 evaluation. For this reason, we explored the potential prognostic role of Ki67 proliferative index in a large series of MCCs using the WHO standardized method of counting positive cells in at least 500 tumor cells in hot spot areas on camera-captured printed images. In addition, since MCC may be considered as the cutaneous counterpart of digestive neuroendocrine carcinomas (NECs), we decided to stratify MCCs using the available and efficient Ki67 threshold of 55%, which was found prognostic in digestive NECs. This choice was also supported by the Youden index analysis. In addition, we analyzed the prognostic value of other clinico-pathologic parameters using both univariate and multivariate analysis. Ki67 index appeared significantly associated with prognosis at univariate analysis together with stage IV, lack of MCPyV, and p63 expression, but not at the multivariate analysis, where survival resulted independently influenced by p63 expression and tumor stage, only.
Keywords
Disease-specific survival, Ki67 standardized count, Merkel cell carcinoma, Overall survival, Prognosis
Pubmed
Web of science
Open Access
Yes
Create date
24/07/2020 13:43
Last modification date
05/12/2020 7:21
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