Screening strategy for Chagas disease in a non-endemic country (Switzerland): a prospective evaluation.

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Version: Final published version
License: CC BY-NC-ND 4.0
Serval ID
serval:BIB_E35D8659AE2C
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Screening strategy for Chagas disease in a non-endemic country (Switzerland): a prospective evaluation.
Journal
Swiss medical weekly
Author(s)
Da Costa-Demaurex C., Cárdenas M.T., Aparicio H., Bodenmann P., Genton B., D'Acremont V.
ISSN
1424-3997 (Electronic)
ISSN-L
0036-7672
Publication state
Published
Issued date
25/03/2019
Peer-reviewed
Oui
Volume
149
Pages
w20050
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
The WHO recommends screening of Latin American migrants for Chagas disease to reduce morbidity and mortality and increase the likelihood of eradicating the disease. The objective was to assess the feasibility and acceptability of a screening strategy in one Swiss canton. From February 2011 to September 2012, people attending six healthcare centres of different types were offered a rapid diagnostic test if they or their mother were of Latin American origin (or, at the blood donation centre, if they had travelled for ≥1 year in Latin America). In addition, testing was offered during events where Latin Americans gathered. In total, 1,010 people were tested, mainly originating from Brazil (24%), Ecuador (13%) and Chile (10%). 54% were born in Latin America, 15% had a Latin American mother, and 29% were travellers. The prevalence of Chagas disease was 2.3% among migrants (15.5% in the community testing) and 0% among travellers. The prevalence was 18.0%, 0.8%, 0.5% and 0% among Bolivians, Ecuadorians, Brazilians and other countries respectively. Predictors for Chagas disease were: born in Latin America (OR = infinite, p <0.001), Bolivian origin (OR = 95, 95% CI: 19–482, p <0.001), being tested in the community (OR = 56, 95% CI: 14–218, p <0.001), and age >35 years OR = 3.4, 95% CI: 1.1–10.5, p = 0.03). The prevalence of Chagas disease was much higher in people attending social events than healthcare centres, suggesting that observations based only on health facility data underestimate the real prevalence of Chagas disease. Screening in the community was well accepted and should be promoted to reach the population at highest risk.
Keywords
Adolescent, Adult, Aged, Chagas Disease/diagnosis, Chagas Disease/epidemiology, Chagas Disease/ethnology, Child, Feasibility Studies, Female, Humans, Latin America/ethnology, Male, Mass Screening/methods, Middle Aged, Prevalence, Prospective Studies, Switzerland/epidemiology, Transients and Migrants/statistics & numerical data, Young Adult
Pubmed
Web of science
Open Access
Yes
Create date
15/04/2019 16:42
Last modification date
03/05/2020 7:02
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