Expression of Melan-A/MART-1 antigen as a prognostic factor in primary cutaneous melanoma

Details

Serval ID
serval:BIB_E31F8AB643B9
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Expression of Melan-A/MART-1 antigen as a prognostic factor in primary cutaneous melanoma
Journal
International Journal of Cancer
Author(s)
Berset  M., Cerottini  J. P., Guggisberg  D., Romero  P., Burri  F., Rimoldi  D., Panizzon  R. G.
ISSN
0020-7136 (Print)
Publication state
Published
Issued date
01/2001
Volume
95
Number
1
Pages
73-7
Notes
Journal Article --- Old month value: Jan 20
Abstract
In this study we assessed the expression of the Melan-A/MART-1 antigen by immunohistochemistry using monoclonal antibody A103 in 73 primary cutaneous melanomas and its correlation with tumor staging and patient survival. Melan-A/MART-1 was expressed in 90% of primary tumors, with loss of expression increasing with Breslow thickness. Kaplan-Meier analysis demonstrated a significantly reduced disease-free interval and overall survival rate for patients not expressing this antigen. The poor prognosis of such patients was even worse for those presenting with a primary melanoma and a Breslow thickness of > or = 1 mm. Thus, Melan-A/MART-1 is not only a useful and specific additional marker for the diagnosis of primary cutaneous melanoma, but it may also help refine the prognosis of patients with malignant melanoma.
Keywords
Antigens, Neoplasm Disease Progression Disease-Free Survival Female Humans Immunohistochemistry Male Melanoma/*diagnosis/*metabolism Multivariate Analysis Neoplasm Proteins/*biosynthesis Prognosis Skin Neoplasms/*diagnosis/*metabolism Time Factors
Pubmed
Web of science
Create date
28/01/2008 11:28
Last modification date
20/08/2019 16:06
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