Notch signaling in the immune system.

Details

Serval ID
serval:BIB_E3108B8FCC11
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Notch signaling in the immune system.
Journal
Immunity
Author(s)
Radtke F., Fasnacht N., Macdonald H.R.
ISSN
1097-4180[electronic], 1074-7613[linking]
Publication state
Published
Issued date
2010
Volume
32
Number
1
Pages
14-27
Language
english
Abstract
The Notch signaling pathway regulates many aspects of embryonic development, as well as differentiation processes and tissue homeostasis in multiple adult organ systems. Disregulation of Notch signaling is associated with several human disorders, including cancer. In the last decade, it became evident that Notch signaling plays important roles within the hematopoietic and immune systems. Notch plays an essential role in the development of embryonic hematopoietic stem cells and influences multiple lineage decisions of developing lymphoid and myeloid cells. Moreover, recent evidence suggests that Notch is an important modulator of T cell-mediated immune responses. In this review, we discuss Notch signaling in hematopoiesis, lymphocyte development, and function as well as in T cell acute lymphoblastic leukemia.
Keywords
Animals, B-Lymphocytes/cytology, B-Lymphocytes/immunology, Cell Differentiation/immunology, Humans, Leukemia-Lymphoma, Adult T-Cell/immunology, Receptors, Notch/immunology, Signal Transduction/immunology, T-Lymphocytes/cytology, T-Lymphocytes/immunology
Pubmed
Web of science
Open Access
Yes
Create date
03/02/2011 11:55
Last modification date
20/08/2019 16:06
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