Prognosis in Duke's B colorectal carcinoma: the Jass classification revisited.

Details

Serval ID
serval:BIB_E2FE1578823C
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Prognosis in Duke's B colorectal carcinoma: the Jass classification revisited.
Journal
The European journal of surgery = Acta chirurgica
Author(s)
De Quay N., Cerottini J.P., Albe X., Saraga E., Givel J.C., Caplin S.
ISSN
1102-4151
Publication state
Published
Issued date
1999
Peer-reviewed
Oui
Volume
165
Number
6
Pages
588-92
Language
english
Notes
Publication types: Comparative Study ; Journal Article - Publication Status: ppublish
Abstract
OBJECTIVE: To assess whether Jass staging enhances prognostic prediction in Dukes' B colorectal carcinoma. DESIGN: A historical cohort observational study. SETTING: A university tertiary care centre, Switzerland. SUBJECTS: 108 consecutive patients. INTERVENTIONS: Curative resection of Dukes' B colorectal carcinoma between January 1985 and December 1988, Patients with familial adenomatous polyposis; hereditary non-polyposis colorectal cancer; Crohns' disease; ulcerative colitis and synchronous and recurrent tumours were excluded. A comparable group of 155 consecutive patients with Dukes' C carcinoma were included for reference purposes. MAIN OUTCOME MEASURES: Disease free and overall survival for Dukes' B and overall survival for Dukes' C tumours. RESULTS: Dukes' B tumours in Jass group III or with an infiltrated margin had a significantly worse disease-free survival (p = 0.001 and 0.0001, respectively) and those with infiltrated margins had a significantly worse overall survival (p = 0.002). Overall survival among those with Dukes' B Jass III and Dukes' B with infiltrated margins was no better than overall survival among all patients with Dukes' C tumours. CONCLUSION: Jass staging and the nature of the margin of invasion allow patients undergoing curative surgery for Dukes' B colorectal carcinoma to be separated into prognostic groups. A group of patients with Dukes' B tumours whose prognosis is inseparable from those with Dukes' C tumours can be identified, the nature of the margin of invasion being used to classify a larger number of patients.
Keywords
Aged, Cohort Studies, Colorectal Neoplasms, Disease-Free Survival, Female, Humans, Male, Neoplasm Staging, Prognosis
Pubmed
Web of science
Create date
28/01/2008 8:56
Last modification date
20/08/2019 16:06
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