Management of invasive candidiasis and candidemia in adult non-neutropenic intensive care unit patients: Part I. Epidemiology and diagnosis

Details

Serval ID
serval:BIB_E2F6DCB40AD6
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Management of invasive candidiasis and candidemia in adult non-neutropenic intensive care unit patients: Part I. Epidemiology and diagnosis
Journal
Intensive Care Med
Author(s)
Guery B. P., Arendrup M. C., Auzinger G., Azoulay E., Borges Sa M., Johnson E. M., Muller E., Putensen C., Rotstein C., Sganga G., Venditti M., Zaragoza Crespo R., Kullberg B. J.
ISSN
1432-1238 (Electronic)
ISSN-L
0342-4642
Publication state
Published
Issued date
01/2009
Volume
35
Number
1
Pages
55-62
Language
english
Notes
Guery, Benoit P
Arendrup, Maiken C
Auzinger, Georg
Azoulay, Elie
Borges Sa, Marcio
Johnson, Elizabeth M
Muller, Eckhard
Putensen, Christian
Rotstein, Coleman
Sganga, Gabriele
Venditti, Mario
Zaragoza Crespo, Rafael
Kullberg, Bart Jan
eng
Review
Intensive Care Med. 2009 Jan;35(1):55-62. doi: 10.1007/s00134-008-1338-7. Epub 2008 Oct 30.
Abstract
BACKGROUND: Invasive candidiasis and candidemia are frequently encountered in the nosocomial setting, particularly in the intensive care unit (ICU). OBJECTIVES AND METHODS: To review the current management of invasive candidiasis and candidemia in non-neutropenic adult ICU patients based on a review of the literature and a European expert panel discussion. RESULTS AND CONCLUSIONS: Candida albicans remains the most frequently isolated fungal species followed by C. glabrata. The diagnosis of invasive candidiasis involves both clinical and laboratory parameters, but neither of these are specific. One of the main features in diagnosis is the evaluation of risk factor for infection which will identify patients in need of pre-emptive or empiric treatment. Clinical scores were built from those risk factors. Among laboratory diagnosis, a positive blood culture from a normally sterile site provides positive evidence. Surrogate markers have also been proposed like 1,3 beta-D: glucan level, mannans, or PCR testing. Invasive candidiasis and candidemia is a growing concern in the ICU, apart from cases with positive blood cultures or fluid/tissue biopsy, diagnosis is neither sensitive nor specific. The diagnosis remains difficult and is usually based on the evaluation of risk factors.
Keywords
Biomarkers/blood, Candidiasis/*diagnosis/*epidemiology, Cross Infection/microbiology, Europe/epidemiology, Fungemia/*diagnosis/*epidemiology/microbiology, Humans, *Intensive Care Units, Prevalence, Turkey/epidemiology
Pubmed
Create date
29/04/2021 9:59
Last modification date
30/04/2021 5:38
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