In vitro activities of tigecycline combined with other antimicrobials against multiresistant gram-positive and gram-negative pathogens.

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Serval ID
serval:BIB_E2B8E718B1BF
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
In vitro activities of tigecycline combined with other antimicrobials against multiresistant gram-positive and gram-negative pathogens.
Journal
Journal of Antimicrobial Chemotherapy
Author(s)
Vouillamoz J., Moreillon P., Giddey M., Entenza J.M.
ISSN
1460-2091 (Electronic)
ISSN-L
0305-7453
Publication state
Published
Issued date
2008
Volume
61
Number
2
Pages
371-374
Language
english
Notes
Publication types: Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
OBJECTIVES: To test the activity of tigecycline combined with 16 antimicrobials in vitro against 22 gram-positive and 55 gram-negative clinical isolates.
METHODS: Antibiotic interactions were determined by chequerboard and time-kill methods.
RESULTS: By chequerboard, of 891 organism-drug interactions tested, 97 (11%) were synergistic, 793 (89%) were indifferent and 1 (0.1%) was antagonistic. Among gram-positive pathogens, most synergisms occurred against Enterococcus spp. (7/11 isolates) with the tigecycline/rifampicin combination. No antagonism was detected. Among gram-negative organisms, synergism was observed mainly with trimethoprim/sulfamethoxazole against Serratia marcescens (5/5 isolates), Proteus spp. (2/5) and Stenotrophomonas maltophilia (2/5), with aztreonam against S. maltophilia (3/5), with cefepime and imipenem against Enterobacter cloacae (3/5), with ceftazidime against Morganella morganii (3/5), and with ceftriaxone against Klebsiella pneumoniae (3/5). The only case of antagonism occurred against one S. marcescens with the tigecycline/imipenem combination. Selected time-kill assays confirmed the bacteriostatic interactions observed by the chequerboard method. Moreover, they revealed a bactericidal synergism of tigecycline with piperacillin/tazobactam against one penicillin-resistant Streptococcus pneumoniae and with amikacin against Proteus vulgaris.
CONCLUSIONS: Combinations of tigecycline with other antimicrobials produce primarily an indifferent response. Specific synergisms, especially against enterococci and problematic gram-negative isolates, might be worth investigating in in vitro models and/or in animal models simulating the human environment.
Keywords
Anti-Infective Agents/administration & dosage, Drug Resistance, Multiple, Bacterial/drug effects, Drug Resistance, Multiple, Bacterial/physiology, Drug Therapy, Combination, Gram-Negative Bacteria/drug effects, Gram-Negative Bacteria/physiology, Gram-Positive Bacteria/drug effects, Gram-Positive Bacteria/physiology, Humans, Microbial Sensitivity Tests/methods, Minocycline/administration & dosage, Minocycline/analogs & derivatives
Pubmed
Web of science
Open Access
Yes
Create date
11/03/2008 16:36
Last modification date
25/09/2019 7:11
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