[Transient episode of erythrocytic autoimmunization in a patient alloimmunized at the end of multiple transfusions]

Details

Serval ID
serval:BIB_E263E336ABF5
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
[Transient episode of erythrocytic autoimmunization in a patient alloimmunized at the end of multiple transfusions]
Journal
Schweizerische Medizinische Wochenschrift
Author(s)
Tissot  J. D., Taliano  V., Schneider  P.
ISSN
0036-7672
Publication state
Published
Issued date
04/1991
Peer-reviewed
Oui
Volume
121
Number
15
Pages
532-5
Notes
Case Reports
English Abstract
Journal Article --- Old month value: Apr 13
Abstract
Delayed hemolytic reaction is a well recognized hazard of blood transfusion and occurs mainly in recipients with alloantibodies, due to sensitization to red cell antigens by previous transfusion or pregnancy. Less frequently, such a reaction may be associated with the presence of red cell autoantibodies appearing after alloimmunization. We report the observation of a patient with chronic myelomonocytic leukemia, who presented a transitory episode of delayed hemolysis after multiple transfusions. At first, anti-Kell alloantibodies were identified and, two weeks later, warm "broad-specific" autoantibodies were detected by direct and indirect antiglobulin tests. The anemia was associated with unstable angina. The patient received multiple transfusions and prednisone. After 3 weeks, the transfusion needs diminished and the autoantibodies progressively disappeared from the serum. The direct antiglobulin test was negative 4 months later. This observation illustrates the poorly understood relationships between erythrocytic alloantigen exposure and red cell autoimmunization.
Keywords
Aged Autoantibodies/isolation & purification Autoimmunity Blood Transfusion/*adverse effects Coombs' Test Erythrocytes/*immunology Humans Isoantibodies/*isolation & purification Kell Blood-Group System/immunology Leukemia, Myelomonocytic, Chronic/*therapy Male
Pubmed
Web of science
Create date
19/01/2008 17:30
Last modification date
20/08/2019 16:06
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