Second-Generation Antipsychotics in Adolescent Psychiatric Patients: Metabolic Effects and Impact of an Early Weight Change to Predict Longer Term Weight Gain.

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Version: Author's accepted manuscript
Serval ID
serval:BIB_E2606312F994
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Second-Generation Antipsychotics in Adolescent Psychiatric Patients: Metabolic Effects and Impact of an Early Weight Change to Predict Longer Term Weight Gain.
Journal
Journal of child and adolescent psychopharmacology
Author(s)
Vandenberghe F., Najar-Giroud A., Holzer L., Conus P., Eap C.B., Ambresin A.E.
ISSN
1557-8992 (Electronic)
ISSN-L
1044-5463
Publication state
Published
Issued date
05/2018
Peer-reviewed
Oui
Volume
28
Number
4
Pages
258-265
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
To examine the metabolic profile of adolescents at baseline and to determine the potential predictive power of a 1-month weight gain (WG) on weight changes during longer term second-generation antipsychotic (SGA) treatment.
A retrospective chart review study, including patients between 13 and 18 years of age and treated with SGA, was conducted. Available data at baseline, 1, 3, and 12 months of treatment were recorded.
Four hundred fifty-six patients were included, with a median age of 15 years. Ten percent of the patients were obese (>95th percentile) and abdominal obesity (>90th percentile) was observed in 12% of patients. In a subgroup of 42 patients with both baseline, 1, and 3-month weight data available, WG >4.5% after 1 month was found to be the best predictor (sensitivity: 100; specificity: 66; area under the curve: 83) for a WG >15% after 3 months. After adjusting for potential confounders, a threshold of WG >4% was found as being the best predictor.
A worrisome prevalence of metabolic disorders was observed in an adolescent psychiatric cohort. In such patients, a WG >4% during the first month of treatment should raise concerns about weight controlling strategies. Further research is needed to confirm the present results and to determine the impact of a 1-month WG on a 1-year weight change.
Keywords
Adolescent, Antipsychotic Agents/administration & dosage, Antipsychotic Agents/adverse effects, Female, Humans, Male, Metabolic Diseases/epidemiology, Obesity, Abdominal/epidemiology, Pediatric Obesity/epidemiology, Predictive Value of Tests, Retrospective Studies, Sensitivity and Specificity, Time Factors, Weight Gain/drug effects, metabolic syndrome, second generation antipsychotics, weight gain, weight monitoring
Pubmed
Web of science
Open Access
Yes
Create date
11/01/2018 11:16
Last modification date
20/08/2019 17:06
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