Quinoa as phytopharmaceutical? Urinary elimination of ecdysterone after consumption of quinoa alone and in combination with spinach

Details

Serval ID
serval:BIB_E25232CEFCFD
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Quinoa as phytopharmaceutical? Urinary elimination of ecdysterone after consumption of quinoa alone and in combination with spinach
Journal
Archiv der Pharmazie
Author(s)
Isenmann Eduard, Yuliandra Tasha, Touvleliou Konstantina, Broekmann Matthias, de la Torre Xavier, Botrè Francesco, Diel Patrick, Parr Maria Kristina
ISSN
0365-6233
1521-4184
ISSN-L
0365-6233
Publication state
Published
Issued date
06/2024
Peer-reviewed
Oui
Volume
357
Number
6
Language
english
Abstract
The phytosteroid ecdysterone is classified as an anabolic agent and has been included on the monitoring list of the World Anti-Doping Agency since 2020. Therefore, the consumption of food rich in ecdysterone, such as quinoa and spinach, is the focus of a lively debate. Thus, the urinary excretion of ecdysterone and its metabolites in humans was investigated following quinoa consumption alone and in combination with spinach. Eight participants (four male and four female) were included, and they ingested 368 ± 61 g cooked quinoa alone and in combination with 809 ± 115 g spinach after a washout. Post-administration urines were analyzed by LC-MS/MS. After intake of both preparations, ecdysterone and two metabolites were excreted in the urine. The maximum concentration of ecdysterone ranged from 0.44 to 5.5 µg/mL after quinoa and from 0.34 to 4.1 µg/mL after quinoa with spinach. The total urinary excreted amount as parent drug plus metabolites was 2.61 ± 1.1% following quinoa intake and 1.7 ± 0.9% in combination with spinach. Significant differences were found in the total urinary excreted amount of ecdysterone, 14-deoxy-ecdysterone, and 14-deoxy-poststerone. Only small portions of ecdysterone from quinoa and the combination with spinach were excreted in the urine, suggesting that both quinoa and spinach are poor sources of ecdysterone in terms of bioavailability.
Pubmed
Web of science
Open Access
Yes
Create date
04/03/2024 17:56
Last modification date
09/08/2024 15:51
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