[Recombinant Monoclonal Antibodies, from Tumor Targeting to Cancer Immunotherapy: A Critical Overview].

Details

Serval ID
serval:BIB_E249D7670063
Type
Article: article from journal or magazin.
Collection
Publications
Title
[Recombinant Monoclonal Antibodies, from Tumor Targeting to Cancer Immunotherapy: A Critical Overview].
Journal
Molekuliarnaia biologiia
Author(s)
Mach J.P.
ISSN
0026-8984 (Print)
ISSN-L
0026-8984
Publication state
Published
Issued date
2017
Peer-reviewed
Oui
Volume
51
Number
6
Pages
1024-1038
Language
russian
Abstract
In view of the explosion of the present clinical use of monoclonal antibodies (mAbs), not only in the treatment of cancer, but also of autoimmune diseases, I was asked to review the development of mAbs in tumor diagnosis and therapy, with some illustrations of our own contribution in the field. The initial use of radiolabeled mAbs for tumor targeting and radioimmunotherapy led to the extensive clinical application of unlabeled, "humanized" mAbs for cancer therapy, which I describe with a critical perspective. The introduction of recombinant bispecific antibodies, capable of bridging T lymphocytes with tumor cells and inducing killing of the cancer cells, was found to be mostly active in the treatment of hematological malignancies. Most interestingly, the use of mAbs not directed to the tumor cells, but to inhibitory receptors expressed by cytotoxic T lymphocytes, which trigger them to kill the cancer cells, represents a new form of active cancer immunotherapy. My motivation in writing this review was related to my long-term interactions with several Russian scientists, mentioned at the end of this article.

Keywords
antibodies, bispecific, carcinoembryonic antigen, immunotherapy, rituximab, аnti-tumor antibodies
Pubmed
Web of science
Create date
05/01/2018 10:44
Last modification date
20/08/2019 17:06
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