Circadian and Feeding Rhythms Orchestrate the Diurnal Liver Acetylome.

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State: Public
Version: Final published version
Serval ID
serval:BIB_E24884033C82
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Circadian and Feeding Rhythms Orchestrate the Diurnal Liver Acetylome.
Journal
Cell reports
Author(s)
Mauvoisin D., Atger F., Dayon L., Núñez Galindo A., Wang J., Martin E., Da Silva L., Montoliu I., Collino S., Martin F.P., Ratajczak J., Cantó C., Kussmann M., Naef F., Gachon F.
ISSN
2211-1247 (Electronic)
Publication state
Published
Issued date
15/08/2017
Peer-reviewed
Oui
Volume
20
Number
7
Pages
1729-1743
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Lysine acetylation is involved in various biological processes and is considered a key reversible post-translational modification in the regulation of gene expression, enzyme activity, and subcellular localization. This post-translational modification is therefore highly relevant in the context of circadian biology, but its characterization on the proteome-wide scale and its circadian clock dependence are still poorly described. Here, we provide a comprehensive and rhythmic acetylome map of the mouse liver. Rhythmic acetylated proteins showed subcellular localization-specific phases that correlated with the related metabolites in the regulated pathways. Mitochondrial proteins were over-represented among the rhythmically acetylated proteins and were highly correlated with SIRT3-dependent deacetylation. SIRT3 activity being nicotinamide adenine dinucleotide (NAD) <sup>+</sup> level-dependent, we show that NAD <sup>+</sup> is orchestrated by both feeding rhythms and the circadian clock through the NAD <sup>+</sup> salvage pathway but also via the nicotinamide riboside pathway. Hence, the diurnal acetylome relies on a functional circadian clock and affects important diurnal metabolic pathways in the mouse liver.

Keywords
ARNTL Transcription Factors/deficiency, ARNTL Transcription Factors/genetics, Acetylation, Animals, Circadian Clocks/physiology, Circadian Rhythm/physiology, Cryptochromes/deficiency, Cryptochromes/genetics, Eating/physiology, Liver/enzymology, Lysine, Metabolic Networks and Pathways/physiology, Mice, Mice, Inbred C57BL, Mice, Knockout, Mitochondrial Proteins/genetics, Mitochondrial Proteins/metabolism, NAD/metabolism, Photoperiod, Protein Processing, Post-Translational, Proteome/genetics, Proteome/metabolism, Sirtuin 3/genetics, Sirtuin 3/metabolism, NAD(+), SILAC proteomics, SIRT3, acetylation, circadian clock, liver metabolism
Pubmed
Web of science
Open Access
Yes
Create date
06/09/2017 9:14
Last modification date
17/09/2020 8:24
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