Interferon beta adenoviral gene therapy in a patient with ovarian cancer.

Details

Serval ID
serval:BIB_E23002BB4B8A
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Title
Interferon beta adenoviral gene therapy in a patient with ovarian cancer.
Journal
Nature Clinical Practice Oncology
Author(s)
Sterman D.H., Gillespie C.T., Carroll R.G., Coughlin C.M., Lord E.M., Sun J., Haas A., Recio A., Kaiser L.R., Coukos G., June C.H., Albelda S.M., Vonderheide R.H.
ISSN
1743-4262 (Electronic)
ISSN-L
1743-4254
Publication state
Published
Issued date
2006
Volume
3
Number
11
Pages
633-639
Language
english
Notes
Publication types: Case Reports ; Journal Article ; Research Support, N.I.H., ExtramuralPublication Status: ppublish
Abstract
Background A 47-year-old woman with a history of ovarian cancer and a 6-year disease-free remission presented with dyspnea and increased abdominal girth. The patient was found to have ascites and a large left pleural effusion, both of which contained malignant cells consistent with recurrent ovarian cancer. Her disease progressed despite treatment with chemotherapeutic and hormonal agents. She was then enrolled in a phase I clinical trial of adenoviral-mediated interferon beta gene therapy. Investigations Abdominal and chest CT scans, 2-[(18)F]fluoro-2-deoxyglucose PET scan, viral cultures, interferon cytokine analysis, immunophenotyping, and tumor cytotoxicity analyses. Diagnosis Stage IV ovarian cancer with malignant ascites and pleural effusion. Management Tunneled pleural catheter and intrapleural adenoviral-mediated interferon beta gene therapy.
Keywords
Adenoviridae, Ascites/etiology, Female, Genetic Therapy, Genetic Vectors, Humans, Interferon-beta/genetics, Interferon-beta/therapeutic use, Middle Aged, Ovarian Neoplasms/complications, Ovarian Neoplasms/therapy, Pleural Effusion/etiology, T-Lymphocytes/immunology, Treatment Outcome
Pubmed
Web of science
Create date
14/10/2014 11:43
Last modification date
20/08/2019 16:06
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