L'oxalate: un déchet organique peu soluble, avec conséquences [Oxalate: a poorly soluble organic waste with consequences].

Details

Serval ID
serval:BIB_E1EB3FA6C821
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
L'oxalate: un déchet organique peu soluble, avec conséquences [Oxalate: a poorly soluble organic waste with consequences].
Journal
Praxis
Author(s)
Lu Y., Bonny O.
ISSN
1661-8157 (Print)
ISSN-L
1661-8157
Publication state
Published
Issued date
03/2015
Volume
104
Number
7
Pages
353-359
Language
french
Notes
Publication types: English Abstract ; Journal Article ; ReviewPublication Status: ppublish
Abstract
Oxalate is a highly insoluble metabolic waste excreted by the kidneys. Disturbances of oxalate metabolism are encountered in enteric hyperoxaluria (secondary to malabsorption, gastric bypass or in case of insufficient Oxalobacter colonization), in hereditary hyperoxaluria and in intoxication (ethylene glycol, vitamin C). Hyperoxaluria causes a large spectrum of diseases, from isolated hyperoxaluria to kidney stones and nephrocalcinosis formation, eventually leading to kidney failure and systemic oxalosis with life-threatening deposits in vital organs. New causes of hyperoxaluria are arising recently, in particular after gastric bypass surgery, which requires regular and preemptive monitoring. The treatment of hyperoxaluria involves reduction in oxalate intake and increase in calcium intake. Optimal urine dilution and supplementation with inhibitors of kidney stone formation (citrate) are required. Some conditions may need vitamin B6 supplementation, and the addition of probiotics might be useful in the future. Primary care physicians should identify cases of recurrent calcium oxalate stones and severe hyperoxaluria. Further management of hyperoxaluria requires specialized care.
Keywords
Calcium/administration & dosage, Diagnosis, Differential, Humans, Hyperoxaluria/classification, Hyperoxaluria/complications, Hyperoxaluria, Primary/classification, Hyperoxaluria, Primary/complications, Intestine, Large/microbiology, Kidney Calculi/prevention & control, Kidney Calculi/urine, Oxalates/administration & dosage, Oxalates/urine, Oxalobacter formigenes/physiology, Risk Factors
Pubmed
Create date
14/01/2016 9:40
Last modification date
17/09/2020 8:21
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