Does Mixed Neuroendocrine-Nonneuroendocrine Neoplasm (MiNEN) of the Parathyroid Gland Exist? First Description of a Possible Case.

Details

Serval ID
serval:BIB_E1E2EF6E8F8C
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Does Mixed Neuroendocrine-Nonneuroendocrine Neoplasm (MiNEN) of the Parathyroid Gland Exist? First Description of a Possible Case.
Journal
Head and neck pathology
Author(s)
Di Palma S., Mufaddal M., Iyer V., Sciarra A., La Rosa S.
ISSN
1936-0568 (Electronic)
ISSN-L
1936-055X
Publication state
Published
Issued date
06/06/2020
Peer-reviewed
Oui
Language
english
Notes
Publication types: Journal Article
Publication Status: aheadofprint
Abstract
We describe the histological, histochemical, and immunohistochemical features of an unusual neoplasm of the parathyroid gland showing the histologic criteria of a mixed neuroendocrine-nonneuroendocrine neoplasm (MiNEN). To the best of our knowledge, this is the first report of such a tumor. A 43-year old male presented with acute and severe abdominal pain due to acute pancreatitis. On physical examination a painless lump in the right neck was detected and laboratory analyses revealed hyperparathyroidism (parathormone: 146 pmol/L, normal range 1.05-6.83) and hypercalcemia (calcium level: 3.02 mg/dL, normal range 2.25-2.5), which fell to 2.55 mg/dL after parathyroidectomy. Histologically, the tumor was a parathyroid carcinoma associated with a mucous secreting adenocarcinoma also confirmed by histochemical (Alcian blue-periodic acid Schiff) and immunohistochemical stainings. The present case expands the spectrum of MiNENs that can be found in endocrine organs.
Keywords
Combined tumor, Composite tumor, MiNEN, Mixed neoplasm, Mixed neuroendocrine-nonneuroendocrine neoplasm, Parathyroid gland
Pubmed
Open Access
Yes
Create date
09/06/2020 13:16
Last modification date
13/06/2020 6:26
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