Pathologic ventricular hypertrophy in the offspring of diabetic mothers: a retrospective study.

Details

Serval ID
serval:BIB_E1D8CBBFD223
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Pathologic ventricular hypertrophy in the offspring of diabetic mothers: a retrospective study.
Journal
European heart journal
Author(s)
Ullmo S., Vial Y., Di Bernardo S., Roth-Kleiner M., Mivelaz Y., Sekarski N., Ruiz J., Meijboom E.J.
ISSN
0195-668X
Publication state
Published
Issued date
2007
Peer-reviewed
Oui
Volume
28
Number
11
Pages
1319-25
Language
english
Notes
Publication types: Journal Article - Publication Status: ppublish
Abstract
AIMS: Diabetes in pregnant women is increasing and with that the complications in their offspring. We studied our population of diabetic mothers (2003-2005) for pathologic ventricular hypertrophy (PVH). METHODS AND RESULTS: In our retrospective study of all 87 diabetic pregnancies (92 neonates), 16 were type 1, 17 were type 2, and 54 were gestational diabetes (GD). Haemoglobin glycated (HbA1c) median was 5.8% (5.3-6.5): 17 with HbA1c above normal 2 with congenital heart disease (CHD) and six with PVH. A total of 75 neonates were normal, five had CHD, and 12 had PVH (1/12 died post-natally, 1/12 stillborn, 2/12 required premature delivery, 8/12 normal). The 16 type 1 pregnancies resulted in three neonates with CHD and in 50% PVH, including one death, one premature Cesarean section because of PVH. The 17 neonates of type 2 pregnancies showed in one CHD and in 25% PVH. Of the 54 GD pregnancies, one had CHD and one had PVH. CONCLUSION: Pregnancies of both type 1 and 2 diabetes carry an increased risk for foetal development of PVH compared with those with GD. The insufficient effect of preventive glycaemia controls leads to conclude that although no definite predictive parameters for malignant outcome can be presented, close monitoring of these pregnancies may prevent perinatal catastrophes.
Keywords
Cardiomyopathy, Hypertrophic, Diabetes, Gestational, Diabetic Angiopathies, Echocardiography, Female, Fetal Diseases, Hemoglobin A, Glycosylated, Humans, Infant, Newborn, Pregnancy, Pregnancy Outcome, Pregnancy in Diabetics, Prenatal Exposure Delayed Effects, Retrospective Studies
Pubmed
Web of science
Open Access
Yes
Create date
25/01/2008 12:17
Last modification date
20/08/2019 17:05
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