Leukocyte Count and Coronary Artery Disease Events in People With Human Immunodeficiency Virus: A Longitudinal Study.

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State: Public
Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_E1546C7A7084
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Leukocyte Count and Coronary Artery Disease Events in People With Human Immunodeficiency Virus: A Longitudinal Study.
Journal
Clinical infectious diseases
Author(s)
Avery E.F., Kleynhans J.N., Ledergerber B., Schoepf I.C., Thorball C.W., Kootstra N.A., Reiss P., Ryom L., Braun D.L., Thurnheer M.C., Marzolini C., Seneghini M., Bernasconi E., Cavassini M., Buvelot H., Kouyos R.D., Fellay J., Günthard H.F., Tarr P.E.
Working group(s)
Swiss HIV Cohort Study
Contributor(s)
Anagnostopoulos A., Battegay M., Bernasconi E., Boni J., Braun D.L., Bucher H.C., Calmy A., Cavassini M., Ciuffi A., Dollenmaier G., Egger M., Elzi L., Fehr J., Fellay J., Furrer H., Fux C.A., Gunthard H.F., Haerry D., Hasse B., Hirsch H.H., Hoffmann M., Hosli I., Huber M., Kahlert C.R., Kaiser L., Keiser O., Klimkait T., Kouyos R.D., Kovari H., Ledergerber B., Martinetti G., de Martinez T.B., Marzolini C., Metzner K.J., Muller N., Nicca D., Paioni P., Pantaleo G., Perreau M., Rauch A., Rudin C., Scherrer A.U., Schmid P., Speck R., Stockle M., Tarr P., Trkola A., Vernazza P., Wandeler G., Weber R., Yerly S.
ISSN
1537-6591 (Electronic)
ISSN-L
1058-4838
Publication state
Published
Issued date
08/06/2023
Peer-reviewed
Oui
Volume
76
Number
11
Pages
1969-1979
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
People with human immunodeficiency virus (HIV; PWH) have increased cardiovascular risk. Higher leukocyte count has been associated with coronary artery disease (CAD) events in the general population. It is unknown whether the leukocyte-CAD association also applies to PWH.
In a case-control study nested within the Swiss HIV Cohort Study, we obtained uni- and multivariable odds ratios (OR) for CAD events, based on traditional and HIV-related CAD risk factors, leukocyte count, and confounders previously associated with leukocyte count.
We included 536 cases with a first CAD event (2000-2021; median age, 56 years; 87% male; 84% with suppressed HIV RNA) and 1464 event-free controls. Cases had higher latest leukocyte count before CAD event than controls (median [interquartile range], 6495 [5300-7995] vs 5900 [4910-7200]; P < .01), but leukocytosis (>11 000/µL) was uncommon (4.3% vs 2.1%; P = .01). In the highest versus lowest leukocyte quintile at latest time point before CAD event, participants had univariable CAD-OR = 2.27 (95% confidence interval, 1.63-3.15) and multivariable adjusted CAD-OR = 1.59 (1.09-2.30). For comparison, univariable CAD-OR for dyslipidemia, diabetes, and recent abacavir exposure were 1.58 (1.29-1.93), 2.19 (1.59-3.03), and 1.73 (1.37-2.17), respectively. Smoking and, to a lesser degree, alcohol and ethnicity attenuated the leukocyte-CAD association. Leukocytes measured up to 8 years before the event were significantly associated with CAD events.
PWH in Switzerland with higher leukocyte counts have an independently increased risk of CAD events, to a degree similar to traditional and HIV-related risk factors.
Keywords
Humans, Male, Middle Aged, Female, Coronary Artery Disease/epidemiology, Coronary Artery Disease/complications, Longitudinal Studies, HIV, Case-Control Studies, Cohort Studies, Risk Factors, Leukocyte Count, HIV Infections/complications, HIV Infections/drug therapy, HIV Infections/epidemiology, HIV infection, coronary artery disease, leukocytes, multivariable analysis, white blood cells
Pubmed
Web of science
Open Access
Yes
Create date
31/01/2023 16:41
Last modification date
06/08/2024 7:02
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