Rapid activation of the alternative pathway of complement by extracorporeal membrane oxygenation

Details

Serval ID
serval:BIB_E145B34DC7B4
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Title
Rapid activation of the alternative pathway of complement by extracorporeal membrane oxygenation
Journal
ASAIO Journal
Author(s)
Vallhonrat  H., Swinford  R. D., Ingelfinger  J. R., Williams  W. W., Ryan  D. P., Tolkoff-Rubin  N., Cosimi  A. B., Pascual  M.
ISSN
1058-2916
Publication state
Published
Issued date
02/1999
Peer-reviewed
Oui
Volume
45
Number
1
Pages
113-4
Notes
Case Reports
Clinical Trial
Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jan-Feb
Abstract
Extracorporeal membrane oxygenation (ECMO) is an effective therapy for patients with severe respiratory distress syndromes. However, an inflammatory response has been observed with the use of this therapy. We measured complement activation in vivo in two adults receiving ECMO for acute respiratory distress syndrome (ARDS). Production of complement activation fragments C4d, Bb, iC3b, and SC5b-9 was determined using commercial ELISA kits. In both patients there was intense activation of complement that peaked 1 hour (mean SC5b-9 increase to 1135% of baseline) after the start of ECMO and occurred predominantly via the alternative pathway (Bb production). Early and acute complement activation may be responsible for the initiation of the inflammatory response that has been observed in patients treated with ECMO.
Keywords
Adult Biological Markers/blood *Complement Activation Complement C3b/analysis Complement C4/analysis *Complement C4b Enzyme-Linked Immunosorbent Assay Extracorporeal Membrane Oxygenation/*adverse effects Fatal Outcome Female Humans Inflammation/*immunology Male Middle Aged Peptide Fragments/analysis/*blood Respiratory Distress Syndrome, Adult/immunology/therapy
Pubmed
Web of science
Create date
29/01/2008 14:52
Last modification date
20/08/2019 17:05
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