The interplay of hypoxic and mental stress: Implications for anxiety and depressive disorders.

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State: Public
Version: Final published version
License: CC BY-NC-ND 4.0
Serval ID
serval:BIB_E14047ED1AFF
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
The interplay of hypoxic and mental stress: Implications for anxiety and depressive disorders.
Journal
Neuroscience and biobehavioral reviews
Author(s)
Burtscher J., Niedermeier M., Hüfner K., van den Burg E., Kopp M., Stoop R., Burtscher M., Gatterer H., Millet G.P.
ISSN
1873-7528 (Electronic)
ISSN-L
0149-7634
Publication state
Published
Issued date
07/2022
Peer-reviewed
Oui
Volume
138
Pages
104718
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
Adequate oxygen supply is essential for the human brain to meet its high energy demands. Therefore, elaborate molecular and systemic mechanism are in place to enable adaptation to low oxygen availability. Anxiety and depressive disorders are characterized by alterations in brain oxygen metabolism and of its components, such as mitochondria or hypoxia inducible factor (HIF)-pathways. Conversely, sensitivity and tolerance to hypoxia may depend on parameters of mental stress and the severity of anxiety and depressive disorders. Here we discuss relevant mechanisms of adaptations to hypoxia, as well as their involvement in mental stress and the etiopathogenesis of anxiety and depressive disorders. We suggest that mechanisms of adaptations to hypoxia (including metabolic responses, inflammation, and the activation of chemosensitive brain regions) modulate and are modulated by stress-related pathways and associated psychiatric diseases. While severe chronic hypoxia or dysfunctional hypoxia adaptations can contribute to the pathogenesis of anxiety and depressive disorders, harnessing controlled responses to hypoxia to increase cellular and psychological resilience emerges as a novel treatment strategy for these diseases.
Keywords
Anxiety, Depressive Disorder/metabolism, Humans, Hypoxia/metabolism, Mitochondria/metabolism, Oxygen/metabolism, Adaptation, Depression, Hypoxia inducible factor, Mitochondria
Pubmed
Web of science
Open Access
Yes
Create date
27/05/2022 14:44
Last modification date
09/03/2023 8:15
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