Single-Cell RNA-Seq Reveals Transcriptional Heterogeneity in Latent and Reactivated HIV-Infected Cells.

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Version: Final published version
Serval ID
serval:BIB_E140228EED10
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Single-Cell RNA-Seq Reveals Transcriptional Heterogeneity in Latent and Reactivated HIV-Infected Cells.
Journal
Cell reports
Author(s)
Golumbeanu M., Cristinelli S., Rato S., Munoz M., Cavassini M., Beerenwinkel N., Ciuffi A.
ISSN
2211-1247 (Electronic)
Publication state
Published
Issued date
24/04/2018
Peer-reviewed
Oui
Volume
23
Number
4
Pages
942-950
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Despite effective treatment, HIV can persist in latent reservoirs, which represent a major obstacle toward HIV eradication. Targeting and reactivating latent cells is challenging due to the heterogeneous nature of HIV-infected cells. Here, we used a primary model of HIV latency and single-cell RNA sequencing to characterize transcriptional heterogeneity during HIV latency and reactivation. Our analysis identified transcriptional programs leading to successful reactivation of HIV expression.
Keywords
HIV, cure, heterogeneity, inducible cell, latency, reactivation, scRNA-seq, signature, single cell, transcriptome
Pubmed
Web of science
Open Access
Yes
Create date
26/04/2018 17:26
Last modification date
20/08/2019 17:05
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