Role of long non-coding RNAs in the determination of β-cell identity.
Details
Serval ID
serval:BIB_E12AF92ED60A
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Role of long non-coding RNAs in the determination of β-cell identity.
Journal
Diabetes, obesity & metabolism
ISSN
1463-1326 (Electronic)
ISSN-L
1462-8902
Publication state
Published
Issued date
09/2016
Peer-reviewed
Oui
Volume
18 Suppl 1
Pages
41-50
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Publication Status: ppublish
Abstract
Pancreatic β-cells are highly specialized cells committed to secrete insulin in response to changes in the level of nutrients, hormones and neurotransmitters. Chronic exposure to elevated concentrations of glucose, fatty acids or inflammatory mediators can result in modifications in β-cell gene expression that alter their functional properties. This can lead to the release of insufficient amount of insulin to cover the organism's needs, and thus to the development of diabetes mellitus. Although most of the studies carried out in the last decades to elucidate the causes of β-cell dysfunction under disease conditions have focused on protein-coding genes, we now know that insulin-secreting cells also contain thousands of molecules of RNA that do not encode polypeptides but play key roles in the acquisition and maintenance of a highly differentiated state. In this review, we will highlight the involvement of long non-coding RNAs (lncRNAs), a particular class of non-coding transcripts, in the differentiation of β-cells and in the regulation of their specialized tasks. We will also discuss the crosstalk between the activities of lncRNAs and microRNAs and present the emerging evidence of a potential contribution of particular lncRNAs to the development of both type 1 and type 2 diabetes.
Keywords
Animals, Cell Differentiation/genetics, Diabetes Mellitus/genetics, Humans, Insulin/secretion, Insulin-Secreting Cells/cytology, Insulin-Secreting Cells/secretion, Mice, RNA, Long Noncoding/genetics, diabetes, insulin, long non-coding RNA, microRNA
Pubmed
Web of science
Open Access
Yes
Create date
23/09/2016 19:36
Last modification date
20/08/2019 17:05