Deficits in cerebral glucose metabolism demonstrated by positron emission tomography in individuals at risk of familial Alzheimer's disease.
Details
Serval ID
serval:BIB_E11AC7967DC1
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Deficits in cerebral glucose metabolism demonstrated by positron emission tomography in individuals at risk of familial Alzheimer's disease.
Journal
Neuroscience Letters
ISSN
0304-3940 (Print)
ISSN-L
0304-3940
Publication state
Published
Issued date
1995
Volume
186
Number
1
Pages
17-20
Language
english
Notes
Publication types: Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Abstract
In order to establish whether positron emission tomography (PET) can identify metabolic changes in Alzheimer's disease at a presymptomatic stage, we have examined 24 asymptomatic at risk individuals from families with Alzheimer's disease. A significant reduction in global cerebral metabolic rate for glucose was found when compared with 16 age-matched controls. There was also a focal, parieto-temporal deficit similar to, although less extensive than, that found in 18 symptomatic individuals from familial Alzheimer's disease (FAD) pedigrees. Follow up of this cohort will establish whether these metabolic changes relate to a presymptomatic stage of the disease.
Keywords
Adult, Aged, Alzheimer Disease/genetics, Alzheimer Disease/metabolism, Amyloid beta-Protein Precursor/genetics, Amyloid beta-Protein Precursor/metabolism, Female, Glucose/metabolism, Humans, Male, Middle Aged, Psychiatric Status Rating Scales, Risk Factors, Tomography, Emission-Computed
Pubmed
Web of science
Create date
16/09/2011 20:59
Last modification date
20/08/2019 17:05