Functional neurogenesis in the adult hippocampus.
Details
Serval ID
serval:BIB_E11A0AAED00D
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Functional neurogenesis in the adult hippocampus.
Journal
Nature
ISSN
0028-0836
Publication state
Published
Issued date
2002
Peer-reviewed
Oui
Volume
415
Number
6875
Pages
1030-1034
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S. Publication Status: ppublish
Abstract
There is extensive evidence indicating that new neurons are generated in the dentate gyrus of the adult mammalian hippocampus, a region of the brain that is important for learning and memory. However, it is not known whether these new neurons become functional, as the methods used to study adult neurogenesis are limited to fixed tissue. We use here a retroviral vector expressing green fluorescent protein that only labels dividing cells, and that can be visualized in live hippocampal slices. We report that newly generated cells in the adult mouse hippocampus have neuronal morphology and can display passive membrane properties, action potentials and functional synaptic inputs similar to those found in mature dentate granule cells. Our findings demonstrate that newly generated cells mature into functional neurons in the adult mammalian brain.
Keywords
Aging/physiology, Animals, Cell Differentiation, Cell Division, Dentate Gyrus/cytology, Female, Genetic Vectors, Green Fluorescent Proteins, Luminescent Proteins, Membrane Potentials, Mice, Mice, Inbred C57BL, Neural Pathways, Neurons/cytology, Neurons/physiology, Synapses
Pubmed
Web of science
Create date
22/01/2010 8:56
Last modification date
20/08/2019 17:05