Preserving of Postnatal Leptin Signaling in Obesity-Resistant Lou/C Rats following a Perinatal High-Fat Diet.

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State: Public
Version: author
Serval ID
serval:BIB_E10F9E8A8E4C
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Preserving of Postnatal Leptin Signaling in Obesity-Resistant Lou/C Rats following a Perinatal High-Fat Diet.
Journal
PloS one
Author(s)
Poher A.L., Arsenijevic D., Asrih M., Dulloo A.G., Jornayvaz F.R., Rohner-Jeanrenaud F., Veyrat-Durebex C.
ISSN
1932-6203 (Electronic)
ISSN-L
1932-6203
Publication state
Published
Issued date
2016
Peer-reviewed
Oui
Volume
11
Number
9
Pages
e0162517
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
Physiological processes at adulthood, such as energy metabolism and insulin sensitivity may originate before or weeks after birth. These underlie the concept of fetal and/or neonatal programming of adult diseases, which is particularly relevant in the case of obesity and type 2 diabetes. The aim of this study was to determine the impact of a perinatal high fat diet on energy metabolism and on leptin as well as insulin sensitivity, early in life and at adulthood in two strains of rats presenting different susceptibilities to diet-induced obesity. The impact of a perinatal high fat diet on glucose tolerance and diet-induced obesity was also assessed. The development of glucose intolerance and of increased fat mass was confirmed in the obesity-prone Wistar rat, even after 28 days of age. By contrast, in obesity-resistant Lou/C rats, an improved early leptin signaling may be responsible for the lack of deleterious effect of the perinatal high fat diet on glucose tolerance and increased adiposity in response to high fat diet at adulthood. Altogether, this study shows that, even if during the perinatal period adaptation to the environment appears to be genetically determined, adaptive mechanisms to nutritional challenges occurring at adulthood can still be observed in rodents.

Keywords
Animals, Blood Glucose/metabolism, Diet, High-Fat, Female, Glucose Tolerance Test, Leptin/metabolism, Male, Obesity/genetics, Postpartum Period, Pregnancy, Rats, Rats, Wistar, Signal Transduction
Pubmed
Web of science
Open Access
Yes
Create date
23/09/2016 19:20
Last modification date
20/08/2019 17:05
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