CD8+ T cells and immunoregulatory networks in asthma.
Details
Serval ID
serval:BIB_E10A5A9671B7
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
CD8+ T cells and immunoregulatory networks in asthma.
Journal
Springer Seminars in Immunopathology
ISSN
0344-4325
Publication state
Published
Issued date
2004
Peer-reviewed
Oui
Volume
25
Number
3-4
Pages
311-323
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Abstract
It is well established that infection with respiratory viruses can cause acute local inflammation in humans and is a leading cause in the hospitalization of asthmatics. Less well recognized is the potential for viral infections to actually protect against the development of asthma, as are the cellular mechanisms which might underlie such protection. This review outlines the basic immunological pathways involved in atopic asthma and details the currently recognized cellular mechanisms induced by respiratory viral infections which can protect against the development of asthma. Specifically, it appears that virus infection induced memory T cells that remain in tissues, e.g. the lung and airways, can under certain circumstances create a local cytokine milieu which inhibits the development of ensuing allergic immune responses at that site. One key aspect of this immune modulation is the cytokine-dependent communication which occurs between the innate and the adaptive immune systems. The mechanistic principles underlying this form of immunomodulation should be taken into consideration when developing future forms of therapy and rational vaccine design.
Keywords
Adjuvants, Immunologic/physiology, Animals, Asthma/immunology, Asthma/metabolism, CD8-Positive T-Lymphocytes/immunology, CD8-Positive T-Lymphocytes/metabolism, Cytokines/physiology, Humans, Hypersensitivity, Immediate/immunology, Hypersensitivity, Immediate/metabolism
Pubmed
Web of science
Create date
18/01/2010 17:09
Last modification date
20/08/2019 17:05