The ovarian cancer oncobiome.
Details
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State: Public
Version: Final published version
License: Not specified
State: Public
Version: Final published version
License: Not specified
Serval ID
serval:BIB_E109B279F39B
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
The ovarian cancer oncobiome.
Journal
Oncotarget
ISSN
1949-2553 (Electronic)
ISSN-L
1949-2553
Publication state
Published
Issued date
30/05/2017
Peer-reviewed
Oui
Volume
8
Number
22
Pages
36225-36245
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Abstract
Humans and other mammals are colonized by microbial agents across the kingdom which can represent a unique microbiome pattern. Dysbiosis of the microbiome has been associated with pathology including cancer. We have identified a microbiome signature unique to ovarian cancers, one of the most lethal malignancies of the female reproductive system, primarily because of its asymptomatic nature during the early stages in development. We screened ovarian cancer samples along with matched, and non-matched control samples using our pan-pathogen array (PathoChip), combined with capture-next generation sequencing. The results show a distinct group of viral, bacterial, fungal and parasitic signatures of high significance in ovarian cases. Further analysis shows specific viral integration sites within the host genome of tumor samples, which may contribute to the carcinogenic process. The ovarian cancer microbiome signature provides insights for the development of targeted therapeutics against ovarian cancers.
Keywords
Animals, Bacteria/genetics, Carcinogenesis, Chromosome Aberrations, Dysbiosis, Female, Fungi/physiology, Helminths/physiology, High-Throughput Nucleotide Sequencing, Humans, Infection/genetics, Infection/microbiology, Infection/parasitology, Infection/virology, Microbiota, Ovarian Neoplasms/genetics, Ovarian Neoplasms/microbiology, Ovarian Neoplasms/parasitology, Ovarian Neoplasms/virology, Transcriptome, Viruses/genetics, microbiome, next generation sequencing, oncobiome, ovarian cancer, pathochip
Pubmed
Web of science
Open Access
Yes
Create date
25/04/2017 20:39
Last modification date
21/11/2022 9:14