Reproducibility of the peritoneal regression grading score for assessment of response to therapy in peritoneal metastasis.

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Serval ID
serval:BIB_E0C8FFB7F363
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Reproducibility of the peritoneal regression grading score for assessment of response to therapy in peritoneal metastasis.
Journal
Histopathology
Author(s)
Solass W., Sempoux C., Carr N.J., Bibeau F., Neureiter D., Jäger T., Di Caterino T., Brunel C., Klieser E., Fristrup C.W., Mortensen M.B., Detlefsen S.
ISSN
1365-2559 (Electronic)
ISSN-L
0309-0167
Publication state
Published
Issued date
06/2019
Peer-reviewed
Oui
Volume
74
Number
7
Pages
1014-1024
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
The four-tiered peritoneal regression grading score (PRGS) assesses the response to chemotherapy in peritoneal metastasis (PM). The PRGS is used, for example, to assess the response to pressurised intraperitoneal aerosol chemotherapy (PIPAC). However, the reproducibility of the PRGS is currently unknown. We aimed to evaluate the inter- and intraobserver variability of the PRGS.
Thirty-three patients who underwent at least three PIPAC treatments as part of the PIPAC-OPC1 or PIPAC-OPC2 clinical trials at Odense University Hospital, Denmark, were included. Prior to each therapy cycle, peritoneal quadrant biopsies were obtained and three haematoxylin and eosin (H&E)-stained step sections were scanned and uploaded to a pseudonymised web library. For determining interobserver variability, eight pathologists assessed the PRGS for each quadrant biopsy, and Krippendorff's alpha and intraclass correlation coefficients (ICCs) were calculated. For determining intraobserver variability, three pathologists repeated their own assessments and Cohen's kappa and ICCs were calculated. A total of 331 peritoneal biopsies were analysed. Interobserver variability for PRGS of each biopsy and for the mean and maximum PRGS per biopsy set was moderate to good/substantial. The intraobserver variability for PRGS of each biopsy and for the mean and maximum PRGS per biopsy set was good to excellent/almost perfect.
Our data support the PRGS as a reproducible and useful tool to assess response to intraperitoneal chemotherapy in PM. Future studies should evaluate the prognostic and predictive role of the PRGS.
Keywords
colorectal cancer, gastric cancer, interobserver variability, ovarian cancer, pancreatic cancer, peritoneal metastasis, pressurized intraperitoneal aerosol chemotherapy (PIPAC), tumor regression grading, pressurised intraperitoneal aerosol chemotherapy, tumour regression grading
Pubmed
Web of science
Create date
05/02/2019 11:53
Last modification date
20/08/2019 17:05
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