The renal hemodynamic effects of Aspirin in newborn and young adult rabbits.

Details

Serval ID
serval:BIB_E0C474E412D0
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
The renal hemodynamic effects of Aspirin in newborn and young adult rabbits.
Journal
Pediatric Nephrology
Author(s)
Drukker A., Mosig D., Guignard J.P.
ISSN
0931-041X
Publication state
Published
Issued date
2001
Peer-reviewed
Oui
Volume
16
Number
9
Pages
713-718
Language
english
Abstract
A group of neonatal (n=10) and 12-week-old (n=12) anesthetized, ventilated New Zealand white rabbits received an acute i.v. dose (40 mg/kg body weight) of acetylsalicylic acid (ASA, Aspirin). In the neonatal animals, i.v. ASA caused within 20 min a significant (P<0.01) fall in renal blood flow and glomerular filtration rate (GFR), with an equally significant (P<0.01) increase in filtration fraction and renal vascular resistance. The latter indicates greatly augmented renal vasconstriction or more precisely reduction in intrarenal vasodilatation by inhibition of vasodilatory prostaglandin (PG) synthesis. Urine volume decreased. The 12-week-old young adult animals responded in a similar, but significantly attenuated fashion. These experiments demonstrate that inhibition of PG synthesis in neonatal animals causes very rapid, reversible vasoconstriction, with a reduction in GFR. In addition, this study confirms previous observations that the renal hemodynamic response to the inhibition of PG synthesis is far more pronounced in neonatal animals than in (young) adult rabbits.
Keywords
Age Factors, Animals, Animals, Newborn, Anti-Inflammatory Agents, Non-Steroidal/pharmacology, Aspirin/pharmacology, Glomerular Filtration Rate/drug effects, Hemodynamics/drug effects, Kidney/drug effects, Kidney/physiology, Prostaglandins/physiology, Rabbits
Pubmed
Web of science
Create date
17/07/2009 16:15
Last modification date
20/08/2019 16:04
Usage data