CORRELATION OF STRUCTURAL AND FUNCTIONAL OUTCOME MEASURES IN A PHASE ONE TRIAL OF CILIARY NEUROTROPHIC FACTOR IN TYPE 2 IDIOPATHIC MACULAR TELANGIECTASIA.

Details

Serval ID
serval:BIB_E0C11C5FAC31
Type
Article: article from journal or magazin.
Collection
Publications
Title
CORRELATION OF STRUCTURAL AND FUNCTIONAL OUTCOME MEASURES IN A PHASE ONE TRIAL OF CILIARY NEUROTROPHIC FACTOR IN TYPE 2 IDIOPATHIC MACULAR TELANGIECTASIA.
Journal
Retina
Author(s)
Sallo F.B., Leung I., Clemons T.E., Peto T., Chew E.Y., Pauleikhoff D., Bird A.C.
Working group(s)
MacTel CNTF Research Group
ISSN
1539-2864 (Electronic)
ISSN-L
0275-004X
Publication state
Published
Issued date
01/2018
Peer-reviewed
Oui
Volume
38 Suppl 1
Number
Suppl 1
Pages
S27-S32
Language
english
Notes
Publication types: Clinical Trial, Phase I ; Journal Article ; Multicenter Study
Publication Status: ppublish
Abstract
Macular telangiectasia Type 2 is a bilateral, progressive, potentially blinding retinal disease characterized by both vascular and neurodegenerative signs. Both the area of the break in the ellipsoid zone seen in "en face" optical coherence tomographic (OCT) images and microperimetric focal retinal sensitivity loss have been proposed as potential measures of progression in macular telangiectasia. The authors aimed to assess the characteristics and interrelationship of these structural and functional disease markers from the data collected in a phase one clinical trial of ciliary neurotrophic factor in macular telangiectasia.
Orthogonal topographic (en face) maps of the ellipsoid zone were generated from Heidelberg Spectralis OCT volume scans (15 × 10° area, 30-μm B-scan intervals) or Zeiss Cirrus HD-OCT 4000 512 × 128 cube scans. Mesopic microperimetry was performed on CenterVue MAIA perimeters, using a Goldmann III stimulus in a custom test grid. Structural and functional data were analyzed by two methods: by calculating aggregate loss and by simple thresholding. The alignment quality of structural and functional data was also evaluated.
Overall, the break area showed a good correlation with aggregate sensitivity loss (ρ = 0.834, P < 0.0001, 95% confidence interval 0.716-0.906) but also with the number of test points below a threshold value (e.g., <20 dB: ρ = 0.843, P < 0.0001, 95% confidence interval 0.755-0.902). Significant misalignment of the MAIA test grid was apparent in 13/48 visits of 7/14 eyes.
The authors found a good correlation between ellipsoid zone break area and function loss. En face OCT mapping of the ellipsoid zone appears to demonstrate structural change before mesopic microperimetry can detect a focal loss of retinal sensitivity. Thresholding offers a quick alternative to calculating aggregate sensitivity loss.
Keywords
Adult, Aged, Biomarkers/metabolism, Ciliary Neurotrophic Factor/metabolism, Disease Progression, Female, Fluorescein Angiography, Fundus Oculi, Humans, Macula Lutea/pathology, Male, Middle Aged, Psychophysics/methods, Telangiectasia, Hereditary Hemorrhagic/diagnosis, Telangiectasia, Hereditary Hemorrhagic/metabolism, Telangiectasia, Hereditary Hemorrhagic/physiopathology, Tomography, Optical Coherence, Visual Field Tests, Visual Fields/physiology, Young Adult
Pubmed
Web of science
Create date
26/09/2024 20:21
Last modification date
27/09/2024 16:46
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