Non-obstructive hydrocephalus associated with intracranial schwannomas: hyperproteinorrhachia as an etiopathological factor?

Details

Serval ID
serval:BIB_E0B6570A112E
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Non-obstructive hydrocephalus associated with intracranial schwannomas: hyperproteinorrhachia as an etiopathological factor?
Journal
Acta Neurochirurgica
Author(s)
Bloch  J., Vernet  O., Aube  M., Villemure  J. G.
ISSN
0001-6268 (Print)
Publication state
Published
Issued date
01/2003
Volume
145
Number
1
Pages
73-8
Language
english
Notes
Journal Article Review --- Old month value: Jan
Abstract
BACKGROUND: This series illustrates the association of communicating hydrocephalus with intracranial non-obstructive schwannomas. This association has commonly been observed, however it has only been reported once previously. Moreover, in all the patients we present, hyperproteinorrhachia was a common denominator. This finding may therefore be the underlying mechanism for hydrocephalus. METHOD AND FINDINGS: Seven patients presenting with intracranial schwannomas along with non-obstructive hydrocephalus and hyperproteinorrhachia are reported. Six had a vestibular schwannoma and presented with a unilateral deafness and various degrees of gait disturbance, urinary incontinence and neuropsychological impairment. Due to their advanced ages, these patients underwent a ventriculo-peritoneal shunt, and their symptoms related to hydrocephalus resolved. One patient that suffered from hemifacial dysesthesia and memory deficits presented with a non-obstructive trigeminal schwannoma. In this case the tumour was removed and the hydrocephalus was consequently reversed, and the CSF protein content normalized. INTERPRETATION: The constant finding of hyperproteinorrhachia in all these patients suggests that a high CSF protein content may be the underlying cause of hydrocephalus through a speculative mechanism of decreased CSF resorption.
Keywords
Adult Aged Brain Neoplasms/*cerebrospinal fluid/*complications/physiopathology Cerebrospinal Fluid Proteins/*cerebrospinal fluid Female Humans Hydrocephalus/*cerebrospinal fluid/*etiology/physiopathology Male Middle Aged Neurilemmoma/*cerebrospinal fluid/*complications/physiopathology
Pubmed
Web of science
Create date
25/01/2008 13:13
Last modification date
20/08/2019 16:04
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