The shaping of invasive glioma phenotype by the ubiquitin-proteasome system.

Details

Serval ID
serval:BIB_E0B27432443F
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
The shaping of invasive glioma phenotype by the ubiquitin-proteasome system.
Journal
Cell Communication and Adhesion
Author(s)
Vlachostergios P.J., Voutsadakis I.A., Papandreou C.N.
ISSN
1543-5180 (Electronic)
ISSN-L
1543-5180
Publication state
Published
Issued date
2013
Volume
20
Number
5
Pages
87-92
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublishDocument Type: Review
Abstract
Abstract Protein degradation is an indispensable process for cells which is often deregulated in various diseases, including malignant conditions. Depending on the specific cell type and functions of expressed proteins, this aberration may have different effects on the determination of malignant phenotypes. A discrete, inherent feature of malignant glioma is its profound invasive and migratory potential, regulated by the expression of signaling and effector proteins, many of which are also subjected to post-translational regulation by the ubiquitin-proteasome system (UPS). Here we provide an overview of this connection, focusing on important pro-invasive protein signals targeted by the UPS.
Pubmed
Web of science
Create date
01/11/2013 20:39
Last modification date
20/08/2019 16:04
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