Exploring viral infection using single-cell sequencing.

Details

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State: Public
Version: Final published version
Serval ID
serval:BIB_E09958353AC9
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Exploring viral infection using single-cell sequencing.
Journal
Virus research
Author(s)
Rato S., Golumbeanu M., Telenti A., Ciuffi A.
ISSN
1872-7492 (Electronic)
ISSN-L
0168-1702
Publication state
Published
Issued date
15/07/2017
Peer-reviewed
Oui
Volume
239
Pages
55-68
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
Single-cell sequencing (SCS) has emerged as a valuable tool to study cellular heterogeneity in diverse fields, including virology. By studying the viral and cellular genome and/or transcriptome, the dynamics of viral infection can be investigated at single cell level. Most studies have explored the impact of cell-to-cell variation on the viral life cycle from the point of view of the virus, by analyzing viral sequences, and from the point of view of the cell, mainly by analyzing the cellular host transcriptome. In this review, we will focus on recent studies that use single-cell sequencing to explore viral diversity and cell variability in response to viral replication.
Keywords
Animals, Computational Biology/methods, Epigenesis, Genetic, Gene Expression Profiling, Genomics/methods, High-Throughput Nucleotide Sequencing, Host-Pathogen Interactions/genetics, Humans, Single-Cell Analysis/methods, Virus Diseases/genetics, Virus Diseases/virology, Virus Physiological Phenomena, Heterogeneity, Single-cell, Single-cell sequencing, Viral infection, Virus
Pubmed
Web of science
Open Access
Yes
Create date
30/11/2016 21:09
Last modification date
20/08/2019 16:04
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