Proof of principle: The effect of antimuscarinics on bladder filling sensations in healthy subjects--a placebo controlled double blind investigation using 4 and 8 mg tolterodine extended release.

Details

Serval ID
serval:BIB_E08F635A3C86
Type
Article: article from journal or magazin.
Collection
Publications
Title
Proof of principle: The effect of antimuscarinics on bladder filling sensations in healthy subjects--a placebo controlled double blind investigation using 4 and 8 mg tolterodine extended release.
Journal
Neurourology and Urodynamics
Author(s)
Mehnert U., Reitz A., Youssef S.A., Schurch B.
ISSN
1520-6777 (Electronic)
ISSN-L
0733-2467
Publication state
Published
Issued date
2010
Volume
29
Number
3
Pages
464-469
Language
english
Notes
Publication types: Comparative Study ; Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Abstract
AIMS: There is evidence that antimuscarinic drugs have depressant influence not only on bladder muscle activity, but also on bladder sensations. The aim of this study was to evaluate the effect of a single dose tolterodine extended release (ER) 4 and 8 mg on bladder sensations during filling cystometry.
METHODS: After approval of the local ethics committee, 30 healthy female subjects (23.7 +/- 2.3 years) were included and randomly assigned to three groups: (A) placebo, (B) tolterodine ER 4 mg, and (C) tolterodine ER 8 mg in a double blind manner. Measurements were performed at baseline and 4 hr postmedication in each group, consisting of: (1) Filling cystometry with 25 ml/min at which subjects had to indicate first sensation of filling (FSF), first desire to void (FDV), and strong desire to void (SDV). (2) Uroflowmetry and ultrasound control for residual urine.
RESULTS: In the placebo group, filling volumes at FDV and SDV decreased significantly posttreatment. This effect could not be observed for the tolterodine 8 mg group and only at SDV in the 4 mg group. No significant difference between groups was found regarding uroflowmetry parameters and postvoid residual volume.
CONCLUSIONS: No increase of filling volumes in healthy subjects could be observed with tolterodine. However, the results suggest that tolterodine is able to alleviate irritation caused by repeated catheterization and cystometry. There was no significant influence of tolterodine ER 4 or 8 mg on voiding function.
Keywords
Benzhydryl Compounds/administration & dosage, Cresols/administration & dosage, Double-Blind Method, Female, Humans, Muscarinic Antagonists/administration & dosage, Phenylpropanolamine/administration & dosage, Prospective Studies, Reference Values, Sensation/drug effects, Urinary Bladder/drug effects, Urinary Bladder/physiology, Young Adult
Pubmed
Web of science
Create date
05/11/2014 12:13
Last modification date
20/08/2019 16:04
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