A single session of moderate intensity exercise influences memory, endocannabinoids and brain derived neurotrophic factor levels in men.

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State: Public
Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_E058F2816C67
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
A single session of moderate intensity exercise influences memory, endocannabinoids and brain derived neurotrophic factor levels in men.
Journal
Scientific reports
Author(s)
Marin Bosch B., Bringard A., Logrieco M.G., Lauer E., Imobersteg N., Thomas A., Ferretti G., Schwartz S., Igloi K.
ISSN
2045-2322 (Electronic)
ISSN-L
2045-2322
Publication state
Published
Issued date
13/07/2021
Peer-reviewed
Oui
Volume
11
Number
1
Pages
14371
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
Regular physical exercise enhances memory functions, synaptic plasticity in the hippocampus, and brain derived neurotrophic factor (BDNF) levels. Likewise, short periods of exercise, or acute exercise, benefit hippocampal plasticity in rodents, via increased endocannabinoids (especially anandamide, AEA) and BDNF release. Yet, it remains unknown whether acute exercise has similar effects on BDNF and AEA levels in humans, with parallel influences on memory performance. Here we combined blood biomarkers, behavioral, and fMRI measurements to assess the impact of a single session of physical exercise on associative memory and underlying neurophysiological mechanisms in healthy male volunteers. For each participant, memory was tested after three conditions: rest, moderate or high intensity exercise. A long-term memory retest took place 3 months later. At both test and retest, memory performance after moderate intensity exercise was increased compared to rest. Memory after moderate intensity exercise correlated with exercise-induced increases in both AEA and BNDF levels: while AEA was associated with hippocampal activity during memory recall, BDNF enhanced hippocampal memory representations and long-term performance. These findings demonstrate that acute moderate intensity exercise benefits consolidation of hippocampal memory representations, and that endocannabinoids and BNDF signaling may contribute to the synergic modulation of underlying neural plasticity mechanisms.
Pubmed
Web of science
Open Access
Yes
Create date
15/07/2021 13:54
Last modification date
21/11/2022 8:10
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