No interactions between previously associated 2-hour glucose gene variants and physical activity or BMI on 2-hour glucose levels.

Details

Ressource 1Request a copy Sous embargo indéterminé.
State: Public
Version: author
Serval ID
serval:BIB_E019BF6B6966
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
No interactions between previously associated 2-hour glucose gene variants and physical activity or BMI on 2-hour glucose levels.
Journal
Diabetes
Author(s)
Scott R.A., Chu A.Y., Grarup N., Manning A.K., Hivert M.F., Shungin D., Tönjes A., Yesupriya A., Barnes D., Bouatia-Naji N., Glazer N.L., Jackson A.U., Kutalik Z., Lagou V., Marek D., Rasmussen-Torvik L.J., Stringham H.M., Tanaka T., Aadahl M., Arking D.E., Bergmann S., Boerwinkle E., Bonnycastle L.L., Bornstein S.R., Brunner E., Bumpstead S.J., Brage S., Carlson O.D., Chen H., Chen Y.D., Chines P.S., Collins F.S., Couper D.J., Dennison E.M., Dowling N.F., Egan J.S., Ekelund U., Erdos M.R., Forouhi N.G., Fox C.S., Goodarzi M.O., Grässler J., Gustafsson S., Hallmans G., Hansen T., Hingorani A., Holloway J.W., Hu F.B., Isomaa B., Jameson K.A., Johansson I., Jonsson A., Jørgensen T., Kivimaki M., Kovacs P., Kumari M., Kuusisto J., Laakso M., Lecoeur C., Lévy-Marchal C., Li G., Loos R.J., Lyssenko V., Marmot M., Marques-Vidal P., Morken M.A., Müller G., North K.E., Pankow J.S., Payne F., Prokopenko I., Psaty B.M., Renström F., Rice K., Rotter J.I., Rybin D., Sandholt C.H., Sayer A.A., Shrader P., Schwarz P.E., Siscovick D.S., Stancáková A., Stumvoll M., Teslovich T.M., Waeber G., Williams G.H., Witte D.R., Wood A.R., Xie W., Boehnke M., Cooper C., Ferrucci L., Froguel P., Groop L., Kao W.H., Vollenweider P., Walker M., Watanabe R.M., Pedersen O., Meigs J.B., Ingelsson E., Barroso I., Florez J.C., Franks P.W., Dupuis J., Wareham N.J., Langenberg C.
ISSN
1939-327X (Electronic)
ISSN-L
0012-1797
Publication state
Published
Issued date
2012
Peer-reviewed
Oui
Volume
61
Number
5
Pages
1291-1296
Language
english
Notes
Publication types: Journal Article ; Meta-Analysis Publication Status: ppublish
Abstract
Gene-lifestyle interactions have been suggested to contribute to the development of type 2 diabetes. Glucose levels 2 h after a standard 75-g glucose challenge are used to diagnose diabetes and are associated with both genetic and lifestyle factors. However, whether these factors interact to determine 2-h glucose levels is unknown. We meta-analyzed single nucleotide polymorphism (SNP) × BMI and SNP × physical activity (PA) interaction regression models for five SNPs previously associated with 2-h glucose levels from up to 22 studies comprising 54,884 individuals without diabetes. PA levels were dichotomized, with individuals below the first quintile classified as inactive (20%) and the remainder as active (80%). BMI was considered a continuous trait. Inactive individuals had higher 2-h glucose levels than active individuals (β = 0.22 mmol/L [95% CI 0.13-0.31], P = 1.63 × 10(-6)). All SNPs were associated with 2-h glucose (β = 0.06-0.12 mmol/allele, P ≤ 1.53 × 10(-7)), but no significant interactions were found with PA (P > 0.18) or BMI (P ≥ 0.04). In this large study of gene-lifestyle interaction, we observed no interactions between genetic and lifestyle factors, both of which were associated with 2-h glucose. It is perhaps unlikely that top loci from genome-wide association studies will exhibit strong subgroup-specific effects, and may not, therefore, make the best candidates for the study of interactions.
Keywords
Blood Glucose/genetics, Blood Glucose/metabolism, Body Mass Index, Epigenesis, Genetic, Gene Expression Regulation/physiology, Genotype, Humans, Life Style, Motor Activity/physiology, Polymorphism, Single Nucleotide
Pubmed
Web of science
Open Access
Yes
Create date
02/05/2012 15:29
Last modification date
20/08/2019 17:04
Usage data